纤维连接蛋白在糖尿病足溃疡中的研究进展

发布时间：2018-10-26 21:55

【摘要】：正据估计,15%的糖尿病患者在他们的一生中会发生足溃疡,且溃疡创面难以愈合~[1],是导致糖尿病患者致残、致死的严重慢性并发症之一。糖尿病足治疗是个系统工程,全方位统筹使足部动脉血液供应改善、感染的有效控制和血糖达标,这是治疗的重点~[2]。而纤维连接蛋白(FN)具有促进细胞间、细胞与基质间的粘连,维持细胞形态,促进细胞移动,引导分化,调理吞噬和促进组织修复等多种功能,能显著促进溃疡伤口愈
[Abstract]:It is estimated that 15% of diabetic patients will develop foot ulcers in their lifetime, and the ulcer wound is difficult to heal, which is one of the serious chronic complications that lead to the disability and death of diabetic patients. The treatment of diabetic foot is a systematic engineering, which can improve the blood supply of the foot artery, control the infection effectively and reach the standard of blood sugar. This is the key point of the treatment. Fibronectin (FN) can promote adhesion between cells, between cells and matrix, maintain cell morphology, promote cell movement, guide differentiation, regulate phagocytosis and promote tissue repair, and can significantly promote healing of ulcer wounds.
【作者单位】：湖南省人民医院湖南师范大学第一附属医院;中南大学湘雅医院眼科;
【基金】：国家自然科学基金面上项目(81170823) 湖南省高层次卫生人才“225”工程培养项目资助湖南省中医药管理局2015年重点项目(201533) 湖南省教育厅2016年项目(16C0965) 湖南省科技厅项目(2015JC3011,2015JC3018) 湖南省卫计委2015年计划项目(B2015-70)
【分类号】：R587.2

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