绝经后髋关节炎、骨质疏松症临床血清指标回顾性比较

发布时间：2018-11-27 21:03

【摘要】：目的了解绝经后髋关节炎、绝经后骨质疏松症患者临床血清指标间的联系,探讨两种疾病的临床相关性。方法收集同一医院(本院)绝经后女性临床检测指标,分组:60例髋关节炎、109例骨质疏松症、102例非骨质疏松症(对照组),运用SPSS18.0软件,利用方差分析、二元logistics回归分析等统计学方法回顾性比较、分析临床指标与骨关节炎和骨质疏松的相关性。结果BMI指标及CRP指标、肌酐、甘油三酯、AST、ALT、ALP等部分血清指标没有相关性;骨密度(BMD)指标、骨形成标志物(P1NP)指标呈负相关;但是,骨吸收标志物(β-CTX)指标、血清铁蛋白指标存在相关性。结论绝经后女性髋关节炎和骨质疏松症患者都存在“骨转换增加、破骨活性增加”的影响因素,还存在“铁蓄积”的影响因素,这些现象提示,目前临床中对骨质疏松采用的部分防治方法可能对骨关节炎的治疗具有潜在的临床价值。
[Abstract]:Objective to study the relationship between clinical serum indexes of postmenopausal hip arthritis and postmenopausal osteoporosis. Methods the clinical indexes of postmenopausal women in the same hospital were collected and divided into six groups: 60 cases of hip arthritis, 109 cases of osteoporosis and 102 cases of non-osteoporosis (control group). SPSS18.0 software and ANOVA were used. The correlation of clinical indexes with osteoarthritis and osteoporosis was analyzed retrospectively by binary logistics regression analysis. Results there was no correlation between BMI and CRP, creatinine, triglyceride, AST,ALT,ALP, etc. There was a negative correlation between (BMD) index and P1NP index of bone mineral density (BMD). However, bone resorption markers (尾-CTX) and serum ferritin were correlated. Conclusion in postmenopausal women with hip arthritis and osteoporosis, the factors of "increased bone turnover, increased osteoclast activity" and "iron accumulation" also exist. These phenomena suggest that, The partial prevention and treatment of osteoporosis may be of potential clinical value in the treatment of osteoarthritis.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R580

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