血清鸢尾素与老年2型糖尿病及其代谢参数的相关性

发布时间：2019-01-02 08:59

【摘要】：目的探讨血清鸢尾素与老年2型糖尿病(T2DM)及其代谢参数的相关性。方法选择老年T2DM患者80例作为T2DM组、老年健康体检者80例作为对照组,测定血清鸢尾素及代谢参数水平。结果 T2DM组患者血清鸢尾素水平低于对照组(P0.05),T2DM组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、胰岛素分泌指数、胰岛素抵抗指数均高于对照组(P0.05);T2DM患者血清鸢尾素与FPG、2 h PG、Hb A1c、FINS、胰岛素分泌指数、胰岛素抵抗指数呈负相关(P0.05),与TG、TC、LDL-C无明显相关性(P0.05);FINS和胰岛素抵抗指数是血清鸢尾素的独立负影响因素(P0.05)。结论老年T2DM患者血清鸢尾素水平降低,血清鸢尾素和多种代谢参数呈负相关,FINS和胰岛素抵抗指数是血清鸢尾素的独立负影响因素。
[Abstract]:Objective to investigate the relationship between serum iris and type 2 diabetes mellitus (T2DM) and its metabolic parameters. Methods Eighty elderly patients with T2DM were selected as T2DM group and 80 healthy controls as control group. Serum Iris and metabolic parameters were measured. Results the serum iris level in T2DM group was lower than that in control group (P0.05), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FPG), 2 h postprandial blood glucose (2 h PG),) in T2DM group were significantly lower than those in control group (P0.05). Glycosylated hemoglobin (Hb A1c), fasting insulin (FINS), insulin secretion index and insulin resistance index were higher than those of control group (P0.05). Serum Iris was negatively correlated with FPG,2 h PG,Hb A1cFINS, insulin secretion index and insulin resistance index (P0.05), but not with TG,TC,LDL-C (P0.05). FINS and insulin resistance index were independent negative factors of serum iris (P0.05). Conclusion the level of iris in serum of elderly patients with T2DM was decreased, and the serum iris was negatively correlated with many metabolic parameters. FINS and insulin resistance index were independent negative factors of serum iris.
【作者单位】：台州市第一人民医院内分泌科;
【基金】：浙江省黄岩区科技计划项目(2015050-3)
【分类号】：R587.1

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