前列地尔治疗高龄糖尿病并慢性肾脏病患者疗效和安全性

发布时间：2019-01-19 11:41

【摘要】：目的临床探究在治疗慢性肾脏病合并糖尿病老年患者时,应用前列地尔药物的可行性、优越性。方法选取新乡市第二人民医院2015年3月—2016年3月期间64例因慢性肾病并糖尿病入院治疗的老年患者,按挂号单双数分为两组包括对照组、治疗组,每组32例。对照组行对症治疗,治疗组在此基础上加用前列地尔,观察症状改善情况,统计用药期间患者不良反应情况,同时对患者肾功能恢复情况进行评估。结果治疗后治疗组患者症状改善有效率为90.6%,对照组为78.1%,治疗组较对照组临床病症改善情况好,P0.05;治疗前各组指标差异无意义,P0.05用药后对照组较治疗组患者血清肌酐、尿蛋白含量改善效果差,P0.05;对照组不良反应发生率为15.6%,治疗组为6.3%,治疗组较对照组患者用药不良反应少、用药安全性高,P0.05。结论临床将前列地尔用于糖尿病肾病治疗,能有效疏通血管、促进血液循环恢复,降低尿蛋白含量,患者恢复效果好且用药安全性高。
[Abstract]:Objective to explore the feasibility and superiority of alprostadil in the treatment of elderly patients with chronic kidney disease and diabetes mellitus. Methods from March 2015 to March 2016, 64 elderly patients with chronic nephropathy and diabetes mellitus were selected from Xinxiang second people's Hospital. They were divided into two groups: control group (n = 32) and control group (n = 32). The control group was treated with symptomatic therapy, and the treatment group was treated with alprostadil on this basis to observe the improvement of symptoms, to count the adverse reactions of the patients, and to evaluate the recovery of renal function of the patients. Results the effective rate of symptom improvement was 90.6 in the treatment group and 78.1 in the control group. The improvement of clinical symptoms in the treatment group was better than that in the control group (P0.05). There was no significant difference in serum creatinine and urinary protein content in the control group before treatment, P0.05. the control group was better than the control group in improving serum creatinine and urine protein content (P0.05). The incidence of adverse reactions was 15.6in the control group and 6.3in the treatment group. The adverse drug reaction in the treatment group was less than that in the control group, and the safety of the drug was high (P0.05). Conclusion the clinical application of alprostadil in the treatment of diabetic nephropathy can effectively dredge the blood vessels, promote the recovery of blood circulation and decrease the content of urinary protein.
【作者单位】：新乡市第二人民医院内分泌科;
【分类号】：R587.2;R692.9

【相似文献】