半乳糖凝集素-3的结构特征及对糖脂代谢调控研究进展

发布时间：2019-01-19 12:11

【摘要】：半乳糖凝集素-3(Galectin-3)是半乳糖凝集素家族(Galectins)的核心成员之一,具有多种生物学功能,如调节炎性因子表达、细胞增殖、分化、凋亡、黏附及mRNA剪接等。研究表明,Galectin-3对葡萄糖代谢和脂肪代谢具有重要的调节作用。但关于Galectin-3的作用方式和分子机制却有不同的研究报道。论文综述了Galectin-3的结构特征及其调控糖脂代谢的作用和分子机制,以期为肥胖、糖尿病等代谢性疾病的防治提供参考。
[Abstract]:Galactose agglutinin 3 (Galectin-3) is one of the core members of galactose agglutinin family (Galectins). It has many biological functions, such as regulating the expression of inflammatory factors, cell proliferation, differentiation, apoptosis, adhesion and mRNA splicing. Studies have shown that Galectin-3 plays an important role in regulating glucose metabolism and fat metabolism. However, different studies have been reported on the mechanism and mechanism of Galectin-3. This paper reviews the structural characteristics of Galectin-3 and its role and molecular mechanism in regulating glycolipid metabolism in order to provide references for the prevention and treatment of metabolic diseases such as obesity and diabetes.
【作者单位】：山西师范大学生命科学学院;
【基金】：国家自然科学基金项目(30972091)
【分类号】：R58

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