单唾液酸四己糖神经节苷脂钠联合硫辛酸治疗糖尿病周围神经病变的疗效

发布时间：2019-03-29 15:34

【摘要】：目的探讨单唾液酸四己糖神经节苷脂钠联合硫辛酸治疗糖尿病周围神经病变的临床效果。方法选取80例糖尿病周围神经病变患者随机分为观察组和对照组各40例。两组患者在一般治疗基础上,对照组给予单唾液酸四己糖神经节苷脂钠治疗,观察组给予单唾液酸四己糖神经节苷脂钠联合硫辛酸治疗。治疗前和治疗后测定两组患者肌电图改变情况。结果观察组治疗后的正中神经和腓总神经运动神经传导速度分别高于对照组(P0.05);观察组治疗后正中神经和腓总神经感觉神经传导速度分别高于对照组(P0.05);观察组治疗后总有效率(95.0%)和对照组(75.0%)无差异(P0.05)。结论单唾液酸四己糖神经节苷脂钠联合硫辛酸治疗糖尿病周围神经病变疗效显著。
[Abstract]:Objective to investigate the clinical effect of sodium tetrahexosylganglioside monosialate combined with lipoic acid in the treatment of diabetic peripheral neuropathy. Methods 80 patients with diabetic peripheral neuropathy were randomly divided into observation group (n = 40) and control group (n = 40). On the basis of general treatment, the patients in the control group were treated with sodium monosialate tetrahexose ganglioside and the observation group was treated with monosialic tetrahexose ganglioside sodium combined with lipoic acid. The changes of electromyography (EMG) were measured before and after treatment in two groups. Results the conduction velocity of median nerve and common peroneal nerve in observation group was higher than that of control group (P0.05), and the conduction velocity of median nerve and common peroneal nerve sensory nerve in observation group was higher than that of control group (P0.05). There was no difference in total effective rate (95.0%) between observation group (95.0%) and control group (75.0%) (P0.05). Conclusion single sialic acid tetrahexose ganglioside sodium combined with lipoic acid is effective in the treatment of diabetic peripheral neuropathy.
【作者单位】：南阳市医学高等专科学校临床医学系;
【基金】：河南省高等学校青年骨干教师资助计划项目(2014GGJS-187)
【分类号】：R587.2

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