甘肃省成人骨质疏松流行病学调查及相关因素分析
发布时间：2019-04-01 19:02
【摘要】：目的研究甘肃省成人骨密度的基本情况,了解骨质疏松及骨量减少的患病情况,分析甘肃省成人骨质疏松症的相关因素。方法制定甘肃省城乡居民骨质疏松流行病学调查表,采用分层、整群、随机的方法进行抽样,在甘肃省抽取7个市州作为调查点,对每个调查点的成人(18-79岁)进行抽样调查。所有受调查者均填写骨质疏松症流行病学调查问卷,并进行身高、体重等一般检查,骨密度检查以及骨代谢相关指标检测。结果参与本次流行病学调查人数共13015例,纳入统计分析的有效数据共12085例,有效率为92.85%。男性共5809例,女性共6276例。1.在甘肃省成人(18-79岁)OP患病率为5.28%,男性为4.07%,女性为6.41%;骨量减少患病率为18.28%,男性为18.50%,女性为18.83%;60岁以上人群总体OP患病率为11.42%,其中女性为15.49%,男性为7.98%;绝经后女性OP患病率明显高于未绝经女性(9.63%VS 0.63%)。2.使用多因素Logistic回归分析显示:在女性中,绝经10年以上者患OP的风险远高于绝经时间少于10年者(OR=2.14,95%CI 1.16-3.95,p=0.015)。在男性和女性中都存在这样的规律:和受教育程度为大专及以上人群相比,未接受教育的人群患病风险明显增高(女性:OR=7.38,95%CI 3.67-109.21,p0.001;男性:OR=1.83,95%CI1.24-2.69,p0.001);与BMI≥30kg/m2的人群相比,BMI18.5 kg/m2的人群OP患病风险显著增高(女性:OR=21.01,95%CI 3.67-109.21,p=0.001;男性:OR=16.01,95%CI5.31-48.24,p=0.031);饮酒使得调查对象OP患病风险增加(女性:OR=1.71,95%CI1.08-2.68,p=0.022;男性:OR=2.081,95%CI 1.43-3.02,p0.001);吸烟是男性OP的危险因素(OR=2.79,95%CI 1.39-5.68,p=0.004);有既往骨折史者患病风险显著高于没有既往骨折史者(女性:OR=2.228,95%CI 1.35-3.67,p=0.002;男性:OR=1.04,95%CI 1.32-3.42,p=0.001)。规律补钙在男女性中均是OP的保护性因素(女性:OR=0.55,95%CI 0.42-0.72,p0.001;男性:OR=0.37,95%CI 0.21-0.60,p=0.001);有规律锻炼习惯的人群OP患病风险降低(女性:OR=0.61,95%CI 0.43-0.86,p=0.005;男性:OR=0.57,95%CI 0.41-0.78,p0.001)。3.通过对不同性别各年龄段的骨代谢相关指标的分析显示年龄是影响骨代谢相关指标水平的因素。4.控制了年龄及绝经年限之后的偏相关分析显示:不论在男性还是女性中,OC(男性:r=-0.102,p=0.001;女性:r=-0.183,p0.001)和β-CTX(男性:r=-0.102,p=0.003;女性:r=-0.197,p0.001)与BMD均呈负相关,Ca(r=0.185,p0.001)和P(r=0.261,p0.001)与BMD呈正相关,但这一趋势仅在男性中有统计学意义。结论甘肃省OP的患病率较全国其他地区略低,在50-59岁之后,患病率明显升高,因此对于OP的预防重点应在上述人群;经常参加锻炼、接受日照、规律补钙、大的BMI和受教育程度较高是OP的保护性因素,吸烟、饮酒,既往骨折史使得OP患病风险增加;年龄是影响骨代谢相关指标水平的因素。OC、β-CTX和BMD成负相关,仅在男性中发现血清Ca和P与BMD成正相关。
[Abstract]:Aim to study the basic condition of bone mineral density (BMD) in adults in Gansu province, to understand the prevalence of osteoporosis and bone mass reduction, and to analyze the related factors of osteoporosis in adults in Gansu province. Methods the epidemiological questionnaire of osteoporosis among urban and rural residents in Gansu Province was established. Stratified, cluster and random sampling was carried out in 7 cities and prefectures of Gansu Province. A sample survey of adults (18 to 79 years old) at each survey site was conducted. All subjects filled in the osteoporosis epidemiological questionnaire, and carried out height, weight and other general tests, bone mineral density test and bone metabolism related indicators. Results 13015 cases participated in the epidemiological survey, 12085 cases were effective data, the effective rate was 92.85%. There are 5809 males and 6276 females. In Gansu Province, the prevalence of OP was 5.28%, 4.07% for males and 6.41% for females, 18.28% for males, 18.50% for males and 18.83% for females, respectively, and the prevalence rate of BMD was 18.28% for males, 18.50% for males and 18.83% for females. The prevalence of OP in postmenopausal women was significantly higher than that in non-menopausal women (9.63%VS 0.63%). The overall prevalence of OP was 11.42% in women over 60 years old, 15.49% in women and 7.98% in men, and significantly higher in postmenopausal women (9.63%VS 0.63%). Multivariate Logistic regression analysis showed that the risk of OP was significantly higher in women with menopause more than 10 years (OR=2.14,95%CI 1.16, 3.95, p < 0.015). The risk of OP was significantly higher in women with menopause than 10 years after menopause (OR=2.14,95%CI 1.16, 3.95, p < 0.015). There was a pattern in both men and women: uneducated people had a significantly higher risk than those with a higher education level (female: OR=7.38,95%CI 3.67 / 109.21, p 0.001); Compared with those with BMI 鈮，
本文编号：2451799
[Abstract]:Aim to study the basic condition of bone mineral density (BMD) in adults in Gansu province, to understand the prevalence of osteoporosis and bone mass reduction, and to analyze the related factors of osteoporosis in adults in Gansu province. Methods the epidemiological questionnaire of osteoporosis among urban and rural residents in Gansu Province was established. Stratified, cluster and random sampling was carried out in 7 cities and prefectures of Gansu Province. A sample survey of adults (18 to 79 years old) at each survey site was conducted. All subjects filled in the osteoporosis epidemiological questionnaire, and carried out height, weight and other general tests, bone mineral density test and bone metabolism related indicators. Results 13015 cases participated in the epidemiological survey, 12085 cases were effective data, the effective rate was 92.85%. There are 5809 males and 6276 females. In Gansu Province, the prevalence of OP was 5.28%, 4.07% for males and 6.41% for females, 18.28% for males, 18.50% for males and 18.83% for females, respectively, and the prevalence rate of BMD was 18.28% for males, 18.50% for males and 18.83% for females. The prevalence of OP in postmenopausal women was significantly higher than that in non-menopausal women (9.63%VS 0.63%). The overall prevalence of OP was 11.42% in women over 60 years old, 15.49% in women and 7.98% in men, and significantly higher in postmenopausal women (9.63%VS 0.63%). Multivariate Logistic regression analysis showed that the risk of OP was significantly higher in women with menopause more than 10 years (OR=2.14,95%CI 1.16, 3.95, p < 0.015). The risk of OP was significantly higher in women with menopause than 10 years after menopause (OR=2.14,95%CI 1.16, 3.95, p < 0.015). There was a pattern in both men and women: uneducated people had a significantly higher risk than those with a higher education level (female: OR=7.38,95%CI 3.67 / 109.21, p 0.001); Compared with those with BMI 鈮，
本文编号：2451799
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