糖尿病胃轻瘫患者肠道菌群分布及炎症因子水平变化的观察

发布时间：2019-05-09 06:03

【摘要】：目的观察糖尿病胃轻瘫(DGP)患者肠道菌群的分布特点及炎症因子水平的变化。方法选取DGP患者(DGP组)126例、单纯糖尿病患者(DM组)100例及健康体检者(NC组)100名。收集各组一般资料和生化指标,检测肠道菌群数量和炎症因子水平。采用多元Logistic回归分析DGP的危险因素。结果 DGP组和DM组FPG、1hPG、2hPG、3hPG及HbA1c均高于NC组(P0.05或P0.01),DGP组糖尿病病程、FPG、3hPG及HbA1c高于DM组,2hPG低于DM组(P0.05);NC组、DM组和DGP组肠杆菌逐渐升高[(7.14±0.28)vs(10.26±0.90)vs(15.54±1.11)CFU/g],拟杆菌[(12.94±1.43)vs(9.45±1.68)vs(7.99±1.46)CFU/g]、双歧杆菌[(11.47±0.52)vs(8.06±0.48)vs(6.35±0.49)CFU/g]及乳酸杆菌[(10.52±0.68)vs(7.77±0.55)vs(5.31±0.42)CFU/g]逐渐降低(P0.05或P0.01);DGP组、DM组和NC组TNF-α、IL-6、IL-1β及C-RP逐渐降低,IL-10和IL-2逐渐升高(P0.05或P0.01);多元Logistic回归分析显示,糖尿病病程、HbA1c、肠杆菌、TNF-α、IL-6及IL-10是DGP的影响因素(P0.05或P0.01)。结论 DGP患者肠道益生菌减少、抗炎因子水平降低,致病菌增多,炎症因子水平升高。肠杆菌、TNF-α、IL-6及IL-10可能在DGP的发生发展中起重要作用。
[Abstract]:Objective to observe the distribution of intestinal flora and the changes of inflammatory factors in patients with diabetic gastroparesis (DGP). Methods 126 patients with DGP (DGP group), 100 patients with simple diabetes mellitus (DM group) and 100 healthy controls (NC group) were selected. The general data and biochemical indexes were collected to detect the number of intestinal flora and the level of inflammatory factors. Multivariate Logistic regression was used to analyze the risk factors of DGP. Results FPG,1hPG,2hPG,3hPG and HbA1c in DGP group and DM group were higher than those in NC group (P0.05 or P0.01), FPG,3hPG and HbA1c were higher in), DGP group than in DM group, 2hPG was lower than DM group (P0.05). In NC group, DM group and DGP group, Enterobacter spp increased gradually [(7.14 卤0.28) vs (10.26 卤0.90) vs (15.54 卤1.11) CFU/g], and Bacteroid bacilli [(12.94 卤1.43) vs (9.45 卤1.68) vs (7.99 卤1.46) CFU/g]. Bifidobacterium [(11.47 卤0.52) vs (8.06 卤0.48) vs (6.35 卤0.49) CFU/g] and Lactobacillus [(10.52 卤0.68) vs (7.77 卤0.55) vs (5.31 卤0.42) CFU/g] decreased gradually ( (P0.05 or P0.01); In DGP group, DM group and NC group, TNF- 伪, IL-6,IL-1 尾 and C-RP decreased gradually, while IL-10 and IL-2 increased gradually (P 0.05 or P 0.01). Multiple Logistic regression analysis showed that the course of diabetes, HbA1c, Enterobacter, TNF- 伪, IL-6 and IL-10 were the influencing factors of DGP (P0.05 or P0.01). Conclusion intestinal probiotics decreased, anti-inflammatory factor level decreased, pathogenic bacteria increased and inflammatory factor level increased in DGP patients. Enterobacteriaceae, TNF- 伪, IL-6 and IL-10 may play an important role in the occurrence and development of DGP.
【作者单位】：南阳市中心医院消化二病区;南阳市中心医院儿科;
【分类号】：R587.2

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