肥胖与50岁以上男性骨质疏松的相关性研究

发布时间：2019-08-02 18:33

【摘要】：目的利用不同人体测量指标,调查分析成都地区50岁以上男性居民中肥胖与骨质疏松的相关性。方法采集在四川大学华西医院进行健康体检的50岁以上男性受检者的临床资料,并测量和计算不同人体测量参数。使用MetriScan手掌骨密度测量仪进行骨密度测定,并根据T值将受试者分为3组(正常骨密度组、骨量减少组和骨质疏松组),比较各组间肥胖的检出率。将体质量指数(BMI)、体圆柱指数(BRI)、腰围、腰高比(WHtR)、腰臀比(WHR)、身体形态指数(ABSI)和身高等人体测量参数分别按四分位数等分为Q1、Q2、Q3、Q4四组,均以Q1组为参照组,采用单因素及年龄矫正后的多元logistic回归分析上述人体测量参数与骨质疏松检出风险的关系。同时计算各指标受试者操作特征(ROC)曲线的曲线下面积(AUC)。结果共纳入9 135例成都地区50岁以上男性居民,其中骨质疏松症的检出率为5.75%(525例)。骨质疏松组各种人体测量参数(BMI、WHR、WHtR、体质量、腰围、臀围、ABSI、BRI等)与骨量减少组和正常骨密度组比较差异具有统计学意义(P0.01)。与最低四分位数(Q1)组相比,BMI、BRI、WHtR、WHR、ABSI、腰围和身高的最高四分位数(Q4)组受检者合并骨质疏松的经年龄矫正的比值比分别为0.443〔95%可信区间(CI):0.342~0.574〕、0.580(95%CI:0.454~0.740)、0.587(95%CI:0.460~0.751)、0.664(95%CI:0.516~0.854)、1.369(95%CI:1.069~1.751)、0.634(95%CI:0.497~0.809)、1.357(95%CI:1.047~1.758)。ROC曲线分析显示,BMI对骨质疏松的AUC为0.606(95%CI:0.580~0.632)。结论肥胖与男性骨质疏松呈一定的负相关,利用BMI测量的肥胖对男性骨质疏松有潜在的预测价值,需要进一步的纵向研究明确其临床意义。
[Abstract]:Objective to investigate the correlation between obesity and osteoporosis in male residents over 50 years old in Chengdu. Methods the clinical data of male subjects over 50 years old who underwent physical examination in Huaxi Hospital of Sichuan University were collected, and different anthropometric parameters were measured and calculated. MetriScan palm bone mineral density instrument was used to measure bone mineral density. According to T value, the subjects were divided into three groups (normal bone mineral density group, bone mass reduction group and osteoporosis group). The detection rate of obesity among groups was compared. The body mass index (BMI), body cylinder index (BRI), waist circumference, waist height ratio (WHtR), waist hip ratio (WHR), body shape index (ABSI) and height were divided into Q1, Q2, Q3, Q4 groups according to the quartile, respectively. The relationship between the above anthropometric parameters and the risk of osteoporosis was analyzed by single factor and age corrected multiple logistic regression. At the same time, the area (AUC). Under the curve of the operating characteristic (ROC) curve of the subjects was calculated. Results A total of 9135 male residents over 50 years old in Chengdu were included, of which the detection rate of osteoporosis was 5.75% (525 cases). There were significant differences in various anthropometric parameters (BMI,WHR,WHtR, body mass, waist circumference, hip circumference, ABSI,BRI, etc.) between osteoporosis group and bone mass reduction group and normal bone mineral density group (P 0.01). Compared with the lowest quartile group (Q1), the age-corrected ratio of BMI,BRI,WHtR,WHR,ABSI, waist circumference to height quartile (Q4) group was 0.443 (95% confidence interval (CI): 0.342 鈮，

本文编号：2522293