解毒滋阴方辅助治疗系统性红斑狼疮的临床疗效及对淋巴细胞亚群和补体水平的影响

发布时间：2019-08-06 08:47

【摘要】：目的:观察解毒滋阴方辅助治疗系统性红斑狼疮的疗效及对淋巴细胞亚群和补体水平的影响。方法:2013年1月~2014年12月在重庆市急救中心就诊的系统性红斑狼疮患者68例按随机数字表分为对照组和观察组各34例,两组患者根据体质量及疾病严重程度口服醋酸泼尼松片,观察组患者在此基础上加服解毒滋阴方,两组患者疗程均为12周。治疗前后比较两组患者的红斑狼疮活动指数(SLEDAI)、疲劳程度(FSS)、中医证候评分(TCMSS)、激素用量及外周血补体C3、Th17和Treg细胞,并比较两组患者的临床疗效和不良反应发生率。结果:(1)治疗前两组患者SLEDAI、TCMSS及FSS评分差异无统计学意义(P0.05),治疗12周观察组SLEDAI、TCMSS及FSS评分较对照组显著降低(P0.01);(2)治疗前两组患者外周血补体C3、Th17及Treg细胞水平差异无统计学意义(P0.05),治疗12周观察组外周血补体C3和Treg细胞水平较对照组显著升高(P0.01),Th17水平较对照组显著降低(P0.01);(3)治疗前两组患者激素用量差异无统计学意义(P0.05),治疗12周时观察组激素用量较对照组显著降低(P0.01),且12周治疗周期内观察组激素总用量较对照组显著降低(P0.01);(4)观察组总有效率显著高于对照组(P0.01);(5)观察组骨质疏松、高血压的发生率及不良反应总发生率显著低于对照组(P0.01)。结论:解毒滋阴方辅助治疗系统性红斑狼疮具有较好的临床疗效,并能提高补体水平以及纠正Th17/Treg失衡。
[Abstract]:Objective: to observe the efficacy of jiedu Ziyin recipe in the treatment of systemic lupus erythematosus (SLE) and its effect on lymphocyte subsets and complement levels. Methods: from January 2013 to December 2014, 68 patients with systemic lupus erythematosus (SLE) in Chongqing Emergency Center were randomly divided into control group (n = 34) and observation group (n = 34). The patients in the two groups were given prednisone acetate tablets according to their body mass and severity of the disease. on this basis, the patients in the observation group were treated with jiedu Ziyin recipe for 12 weeks. Before and after treatment, the lupus erythematosus activity index (SLEDAI), fatigue degree (FSS), TCM syndrome score (TCMSS), hormone dosage and peripheral blood complement C3, Th17 and Treg cells were compared, and the clinical efficacy and adverse reaction incidence of the two groups were compared. Results: (1) there was no significant difference in SLEDAI,TCMSS and FSS scores between the two groups before treatment (P 0.05). The scores of SLEDAI,TCMSS and FSS in the observation group were significantly lower than those in the control group at the 12th week of treatment (P 0.01). (2) there was no significant difference in the levels of complement C3, Th17 and Treg cells between the two groups before treatment (P 0.05). The levels of complement C3 and Treg cells in peripheral blood of the observation group were significantly higher than those of the control group at the 12th week of treatment (P01), and the level of Th17 was significantly lower than that of the control group (P01). (3) there was no significant difference in hormone dosage between the two groups before treatment (P 0.05). At 12 weeks of treatment, the hormone dosage in the observation group was significantly lower than that in the control group (P 0.01), and the total hormone dosage in the observation group was significantly lower than that in the control group during the 12 week treatment cycle (P01); (4). The total effective rate in the observation group was significantly higher than that in the control group (P 0.01). (5) the incidence of osteoporosis, hypertension and total adverse reactions in the observation group were significantly lower than those in the control group (P 0.01). Conclusion: jiedu Ziyin recipe has a good clinical effect in the treatment of systemic lupus erythematosus, and can improve the level of complement and correct the imbalance of Th17/Treg.
【作者单位】：重庆市急救中心;
【分类号】：R593.241

【相似文献】