须癣毛癣菌对三种外用抗真菌药物敏感性研究

发布时间：2018-04-12 10:42

本文选题：抗真菌活性 + 酮康唑乳膏　；参考：《山西医科大学》2017年硕士论文

【摘要】：目的:通过对3种外用抗真菌药物(2%酮康唑乳膏,盐酸布替萘芬乳膏,曲安奈德益康唑乳膏)体外抗真菌活性和药物敏感性进行比较,为临床的合理用药提供参考。方法:选用临床分离须癣毛癣菌15株及其标准株1株,用琼脂扩散法作药敏试验,在琼脂的含菌平板打孔后分别加入上述3种药物,经过7天的培养后测定药孔周围的抑菌圈直径的大小。结果:3种外用药物对须癣毛癣菌的标准菌株和临床菌株均形成抑菌圈,2%酮康唑乳膏抑菌圈直径均数15.94mm,盐酸布替萘芬乳膏抑菌圈直径均数为68.39mm,曲安奈德益康唑乳膏抑菌圈直径均数为62.32mm。而任意2组的抑菌圈均数比较,其差异均有统计学意义(P0.001),2%酮康唑乳膏和盐酸布替萘芬乳膏临床菌株与标准菌株抑菌圈均数比较,其差异均有统计学意义(P0.001)。结论:对于须癣毛癣菌临床菌株和标准菌株而言,盐酸布替萘芬乳膏优于曲安奈德益康唑乳膏,曲安奈德益康唑乳膏优于酮康唑乳膏,须癣毛癣菌临床菌株对于酮康唑乳膏与盐酸布替萘芬乳膏不排除耐药情况的产生。
[Abstract]:Methods: 15 strains and 1 standard strain of Trichophyton versicolor were selected. The drug sensitivity test was performed by Agar diffusion method.After 7 days of culture, the diameter of the bacteriostasis circle around the drug pore was measured.The mean diameter of the inhibition circle was 62.32mm.However, there were significant differences in the mean number of bacteriostatic circles between any two groups (P 0.001) and butenafine hydrochloride cream (P 0.001%). There were significant differences between clinical strains and standard strains (P 0.001).Conclusion: butenafine hydrochloride cream is superior to triamcinolone acetonide econazole cream and triamcinolone acetonide econazole cream is superior to ketoconazole cream for clinical and standard strains of Trichophyton tuber.The clinical strains of Trichophyton rubrum did not rule out drug resistance of ketoconazole cream and butenafine hydrochloride cream.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R756

【参考文献】