梅毒患者243例相关抗体检测结果分析

发布时间：2018-05-01 09:35

  本文选题：快速血浆反应素试验 + 时间分辨荧光免疫法　； 参考：《中国皮肤性病学杂志》2014年11期

【摘要】：目的探讨梅毒患者抗体与年龄、性别、疗程以及不同临床分期的关系,为临床合理化治疗提供参考。方法 243例梅毒患者采用时间分辨荧光免疫法(TRFIA)检测梅毒螺旋体抗体含量,用快速血浆反应素试验(RPR)检测血清中反应素滴度,TRFIA阳性患者用梅毒螺旋体明胶颗粒凝集试验(TPPA)确认。结果梅毒螺旋体特异性抗体的含量各年龄组相互比较差异有统计学意义(P0.01),不同性别间其含量差异无统计学意义(P0.05),恢复期患者梅毒螺旋体特异性抗体的含量显著高于治疗初期(P0.01);RPR≥1∶8患者的数量在19~29岁的人群中所占比例最高(53.06%),其次是胎传梅毒占41.56%,治疗1个月RPR阴转率(6.52%)与三个月的阴转率(16.30%)相比,差异有统计学意义(P0.05)。结论梅毒抗体在不同人群、不同治疗阶段以及不同临床分期中各不相同,在隐性梅毒患者中孕产妇数量较多,应加强对孕产妇梅毒患者的治疗和健康教育工作,减少胎传梅毒的发生率。
[Abstract]:Objective to study the relationship between antibody and age, sex, course of treatment and different clinical stages in syphilis patients, so as to provide reference for rational treatment of syphilis. Methods the levels of Treponema pallidum antibody were detected by time resolved fluorescence immunoassay (TRFIA) in 243 patients with syphilis, and the serum levels of Reagin titer and TRFIA were detected by rapid plasma reactive hormone test (RPRP). TPPAs were confirmed by Treponema pallidum gelatin particle agglutination test (TPPA) in 243 patients with syphilis. Results the content of specific antibody to Treponema pallidum was significantly different among different age groups (P 0.01). There was no significant difference in the content of Treponema pallidum in different sex. The content of specific antibody of Treponema pallidum in convalescent patients was significantly higher. In the early stage of treatment, the number of patients with RPR 鈮，

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