荨麻疹性血管炎23例临床表现和组织病理分析

发布时间：2018-06-01 17:25

本文选题：血管炎 + 荨麻疹　；参考：《中国皮肤性病学杂志》2015年07期

【摘要】：目的进一步了解荨麻疹性血管炎的临床表现和组织病理学特征,提高临床医生对本病的认识。方法回顾性分析23例荨麻疹性血管炎患者的临床表现、实验室检查结果和组织病理学资料。结果该病患者以中年女性居多,临床表现为荨麻疹样皮损,均伴有瘙痒,部分患者伴有疼痛、触痛或烧灼感,部分患者皮疹消退后遗留色素沉着,持续时间均超过24h。皮损组织病理学检查可见真皮浅层血管周围炎症细胞浸润,中性粒细胞为主型8例(34.78%);淋巴细胞为主型15例(65.22%),其中4例(17.39%)合并有中性粒细胞、嗜酸性粒细胞浸润,3例(13.04%)有中性粒细胞浸润,5例(21.74%)有嗜酸性粒细胞浸润,3例(13.04%)仅为淋巴细胞浸润。结论荨麻疹性血管炎的临床表现主要为风团和水肿性红斑,组织病理学特征呈谱系性改变,可以从轻微的血管周围淋巴细胞浸润到典型的白细胞碎裂性血管炎改变。
[Abstract]:Objective to investigate the clinical and histopathological features of urticaria vasculitis and to improve the understanding of the disease. Methods the clinical manifestations, laboratory findings and histopathological data of 23 patients with urticaria vasculitis were retrospectively analyzed. Results Middle-aged women were the majority of the patients. The clinical manifestations were urtica-like lesions with pruritus, some patients with pain, tenderness or burning sensation, and some patients had pigmentation after the rash subsided for more than 24 hours. Histopathological examination showed infiltration of inflammatory cells around the dermis superficial blood vessels, neutrophils in 8 cases, neutrophils in 4 cases, neutrophils in 15 cases of lymphocytic type (65.22%), and neutrophils in 4 cases. Eosinophil infiltration (n = 3) neutrophil infiltration (n = 5) eosinophil infiltration (n = 3) was found in 3 cases (n = 13.04). Conclusion the clinical manifestations of urticaria vasculitis are mainly wind-mass and edematous erythema. The histopathological features of the vasculitis show a pedigree change and may change from mild perivascular lymphocyte infiltration to typical leukocyte fragmentation vasculitis.
【作者单位】：广东省佛山市顺德区慢性病防治中心;复旦大学附属华山医院皮肤科;
【分类号】：R758.24

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