固本汤联合盐酸西替利嗪片治疗慢性荨麻疹的临床疗效观察

发布时间：2018-06-18 16:54

本文选题：慢性荨麻疹 + 固本汤　；参考：《成都中医药大学》2011年硕士论文

【摘要】：的：通过临床观察评价固本汤联合盐酸西替利嗪片治疗慢性荨麻疹的疗效,以讨中西医结合治疗慢性荨麻疹的临床优势。法：将80例慢性荨麻疹患者随机分为两组：治疗组40例,口服固本汤煎剂,次200m1,tid一日三次和盐酸西替利嗪片,10mg,qd；对照组40例,口服盐西替利嗪片,10mg,qd,一个疗程为7天。于治疗开始时、用药第7天、第天及第28天就诊,分别记录两组受试者瘙痒程度、风团大小、皮损分布、皮红斑程度、皮损数量等变化情况。并于治疗后第4周评价近期疗效。果：治疗前两组症状体征评分无显著着性差异(P0.05),治疗后症状体征评差异有显著着性(P0.05)。两组于用药第7天有效率分别为65.79%,62.16%,组比较差异无显著着性(P0.05)；用药第14天有效率分别为78.95%,56.76%,组比较差异无显着性(P0.05)；用药第28天有效率分别为84.21%,75.68%,组比较均差异无显着性(P0.05)。完成治疗后,治疗组症状体征总评分为10.135.89,对照组总评分为8.97±4.63,两组总评分比较,差异有显著着性(P0.05)。良反应：75例患者中共有3例出现不良反应,治疗组1例,对照组2例,主要现为口干、头痛、嗜睡及胃肠道不适。不良反应均较轻微,停药后即消失。论：中西医结合(固本汤与盐酸西替利嗪片)、单纯用西药(盐酸西替利嗪片)疗慢性荨麻疹均可达到良好的短期治疗效果,治疗组与对照组比较,治疗组对善慢性荨麻疹患者的疗效优于对照组,是治疗慢性荨麻疹的一种安全有效的治方案。
[Abstract]:Objective: to evaluate the curative effect of Guben decoction combined with cetirizine hydrochloride in the treatment of chronic urticaria through clinical observation, in order to discuss the clinical advantages of integrated traditional Chinese and western medicine in the treatment of chronic urticaria. Methods: 80 patients with chronic urticaria were randomly divided into two groups: treatment group (n = 40), treated group (n = 40), oral Guben decoction, 200ml / d three times a day and cetirizine hydrochloride tablet (n = 10 mg / d), control group (n = 40), oral salt cettirizine tablets (n = 40) and salcetirizine tablets (n = 40, 10 mg / g QD, a course of treatment was 7 days). At the beginning of treatment, on the 7th, 2nd and 28th day, the changes of pruritus degree, wind mass size, skin lesion distribution, skin erythema degree and the number of skin lesions were recorded. The short-term curative effect was evaluated 4 weeks after treatment. Fruit: before treatment, there was no significant difference in the scores of symptoms and signs between the two groups (P 0.05), but there was significant difference in the evaluation of symptoms and signs after treatment (P 0.05). On the 7th day, the effective rates of the two groups were 65.79 and 62.16, respectively. There was no significant difference between the two groups, but on the 14th day the effective rates were 78.95 and 56.765.The effective rates of the two groups were 84.2175.68 and 84.2175.68, respectively, and there was no significant difference between the two groups. After the treatment, the total score of symptoms and signs was 10.135.89 in the treatment group and 8.97 卤4.63 in the control group. The difference between the two groups was significant (P 0.05). There were 3 cases of adverse reactions in 75 cases of benign reaction, 1 case in the treatment group and 2 cases in the control group. The main symptoms were xerostomia, headache, lethargy and gastrointestinal discomfort. The adverse reactions were mild and disappeared after withdrawal. Conclusion: the treatment of chronic urticaria with traditional Chinese and western medicine (Guben decoction and cetirizine hydrochloride tablets alone) can achieve a good short-term therapeutic effect. The treatment group is compared with the control group. The therapeutic effect of the treatment group on chronic urticaria is better than that of the control group, and it is a safe and effective treatment for chronic urticaria.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.24

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