白芍总苷胶囊联合阿维A和复方氟米松治疗银屑病的临床效果

发布时间：2018-07-17 01:17

【摘要】：目的银屑病存在易复发、难治愈的特点,且采用联合用药治疗银屑病的研究较少。文中旨在研究白芍总苷胶囊(TGP)联合阿维A、复方氟米松治疗寻常性银屑病(PV)的临床效果及对患者外周血细胞因子水平的影响。方法选取2015年10月至2017年1月于苏州大学附属第一医院皮肤科就诊的126例PV患者,随机数字表法分为联合用药组(阿维A+复方氟米松软膏+TGP)和对照组(阿维A+复方氟米松软膏),每组63例。通过对2组患者治疗前后外周血白细胞介素IL-17、IL-18、IL-23等指标水平综合评价临床治疗效果。结果 2组银屑病患者治疗后IL-17、IL-18及IL-23浓度较治疗前均明显降低,联合用药组3项指标下降幅度最大(P0.05);治疗后联合用药组IL-17[(61.18±8.91)pg/m L]、IL-18[(68.56±17.95)pg/m L]及IL-23浓度[(70.13±12.16)pg/m L]均明显低于对照组[(78.64±7.85)、(79.49±18.64)、(91.18±16.89)pg/m L],差异有统计学意义(P0.05)。治疗后联合用药组TNF-α[(14.47±7.53)ng/L]、PASI评分[(4.09±1.29)分]及皮损总面积百分比[(6.17±4.59)%]均明显低于对照组[(23.49±8.12)ng/L、(7.29±5.13)分、(8.09±5.18)%],且较治疗前显著下降,差异有统计学意义(P0.05)。2组不良反应发生率比较差异无统计学意义(P0.05)。联合用药组治疗总有效率较对照组明显升高(85.71%vs 65.08%,P0.05)。结论白芍总苷胶囊联合阿维A、复方氟米松可有效调节IL-17、IL-18、IL-23及TNF-α水平,从而显著提高银屑病的临床治疗效果。
[Abstract]:Objective Psoriasis is easy to relapse and difficult to cure. The aim of this study was to study the clinical effect of total glucoside of paeony (TGP) combined with Avera and compound flutamethasone in the treatment of psoriasis vulgaris (PV) and the effect of TGP on peripheral blood cytokine levels in patients with psoriasis vulgaris. Methods 126 patients with PV were selected from October 2015 to January 2017 in the Department of Dermatology, the first affiliated Hospital of Suzhou University. The patients were randomly divided into two groups: Avera compound flutamethasone ointment (TGP) and control group (Avera compound flumisone ointment) with 63 cases in each group. The clinical therapeutic effect was evaluated by the level of IL-17, IL-18 and IL-23 in peripheral blood before and after treatment. Results the levels of IL-17, IL-18 and IL-23 in patients with psoriasis after treatment were significantly lower than those before treatment. The levels of IL-17 [(61.18 卤8.91) pg/m L] and IL-23 [(68.56 卤17.95) pg/m L] and IL-23 (70.13 卤12.16 pg/m L) in the combined treatment group were significantly lower than those in the control group [(78.64 卤7.85), (79.49 卤18.64), (91.18 卤16.89) pg/m L] after treatment (P0.05). After treatment, the TNF- 伪 [(14.47 卤7.53) ng / L] PASI score [(4.09 卤1.29) scores] and the percentage of total lesion area [(6.17 卤4.59)%] were significantly lower in the combined group than in the control group [(23.49 卤8.12) ng / L, (7.29 卤5.13), (8.09 卤5.18)%]. The total effective rate of the combined treatment group was significantly higher than that of the control group (85.71%vs 65.08 and P0.05). Conclusion Total glucoside capsule of paeony combined with Avera and compound flumisone can effectively regulate the levels of IL-17, IL-18, IL-23 and TNF- 伪, so as to improve the clinical therapeutic effect of psoriasis.
【作者单位】：苏州大学附属第一医院皮肤科;
【分类号】：R758.63

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