大疱性类天疱疮患者并发糖尿病情况分析

发布时间：2018-08-16 08:52

【摘要】：目的了解系统糖皮质激素治疗前后大疱性类天疱疮(BP)患者糖尿病患病情况及临床特点。方法回顾性分析2005年6月-2016年2月北京医院皮肤科和北京大学第三医院皮肤科收治的45例BP患者的临床资料,并与同期90例接受系统性应用糖皮质激素治疗的湿疹患者进行对照分析。结果系统性应用糖皮质激素治疗前,BP组与湿疹组诊断为2型糖尿病者与非2型糖尿病者的性别构成和年龄组成及2型糖尿病患病比例的差异均无统计学意义(P均0.05)。系统性应用糖皮质激素治疗8周后,BP组诊断为2型糖尿病者平均年龄较非糖尿病者大(P0.05),性别差异无统计学意义(P0.05),且BP组患糖皮质激素诱导性糖尿病(GC-DM)比例较湿疹组高(P0.05),BP组和湿疹组患GC-DM者均较未患GC-DM者的年龄大(P0.05)。有代谢综合征病史的BP患者较无该病史者更易发生GC-DM(P0.05)。结论 BP患者较湿疹患者更易发生GC-DM,且年龄越大的BP患者和既往有代谢综合症病史的BP患者更易发生GC-DM。
[Abstract]:Objective to investigate the prevalence and clinical characteristics of diabetes mellitus in patients with bullous pemphigoid (BP) before and after systemic glucocorticoid therapy. Methods from June 2005 to February 2016, the clinical data of 45 BP patients treated in the Dermatology Department of Beijing Hospital and the third Hospital of Peking University were retrospectively analyzed. And 90 cases of eczema treated with glucocorticoid in the same period were analyzed. Results there was no significant difference between BP group and eczema group in sex composition, age composition and prevalence rate of type 2 diabetes mellitus (P 0.05) before systemic use of glucocorticoid. After 8 weeks of systemic glucocorticoid therapy, the average age of patients diagnosed as type 2 diabetes in the BP group was longer than that in the non-diabetic group (P0.05), and there was no significant difference in sex (P0.05), and the proportion of glucocorticoid-induced diabetes mellitus (GC-DM) in the BP group was higher than that in eczema. The patients with GC-DM in high BP group and eczema group were older than those without GC-DM (P0.05). BP patients with a history of metabolic syndrome were more likely to develop GC-DM than those without it (P0.05). Conclusion the patients with BP are more likely to develop GC-DM than those with eczema, and the older BP patients and BP patients with history of metabolic syndrome are more likely to develop GC-DM.
【作者单位】：北京医院皮肤科国家老年医学中心;北京大学第三医院;
【分类号】：R587.1;R758.66

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