成人型黄色肉芽肿20例临床和组织病理分析

发布时间：2019-01-11 07:34

【摘要】：目的:总结成人型黄色肉芽肿的临床表现及组织病理特点。方法:回顾性分析第四军医大学西京皮肤医院于2005年10月—2014年3月诊断的20例成人型黄色肉芽肿患者的临床表现和组织病理特点。结果:20例患者中,男15例,女5例,平均发病年龄为39岁,其中19例为单发皮损,1例为多发。皮损多见于头面颈部,尚未发现皮肤以外器官受累。组织病理表现为表皮轻度萎缩变薄,真皮可见境界清楚但无包膜包绕的细胞团块,由数量不等的组织细胞、Touton巨细胞及多种炎性细胞组成,免疫组化结果显示皮损处浸润细胞CD68阳性,CD1a和S-100蛋白阴性。结论:成人型黄色肉芽肿大多为单发皮损,组织病理学表现为表皮轻度萎缩变薄,真皮可见境界清楚但无包膜包绕的细胞团块,早期为单一形态、无泡沫化的组织细胞浸润,成熟期组织细胞出现泡沫化,伴有Touton巨细胞和多种炎性细胞,晚期常见梭形细胞浸润。
[Abstract]:Objective: to summarize the clinical and histopathological features of adult xanthogranuloma. Methods: the clinical and histopathological features of 20 adult xanthogranuloma patients diagnosed in Xijing skin Hospital of fourth military Medical University from October 2005 to March 2014 were analyzed retrospectively. Results: of the 20 patients, 15 were male and 5 were female. The average age of onset was 39 years old. Among them, 19 cases were single lesions, 1 case was multiple lesions. Skin lesions are more common in the head, face and neck, but no involvement of non-skin organs has been found. The histopathological features were slight atrophy and thinning of the epidermis, clear boundary of dermis but no encapsulated cell mass, consisting of different numbers of histocytes, Touton giant cells and various inflammatory cells. Immunohistochemical results showed that the infiltrating cells in the lesions were CD68 positive, CD1a and S-100 protein were negative. Conclusion: adult xanthogranuloma is mostly a single skin lesion. The histopathological features are slight atrophy and thinning of epidermis, clear boundary of dermis but no encapsulated cell mass, single shape in early stage and no infiltration of foamed tissue cells. In the mature stage, the cells were foamed, accompanied by Touton giant cells and various inflammatory cells, and spindle cells infiltrated in the late stage.
【作者单位】：第四军医大学西京皮肤医院;
【分类号】：R758.6

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