复方甘草酸苷联合窄谱UVB治疗玫瑰糠疹的Meta分析

发布时间：2019-01-11 13:35

【摘要】：目的:系统评价复方甘草酸苷联合窄谱UVB治疗玫瑰糠疹的疗效及安全性。方法:利用计算机检索Pubmed、Cochrane library、Em BASE资源库、中国知网、维普资源平台、万方数据平台中有关复方甘草酸苷联合窄谱UVB治疗玫瑰糠疹疗效和安全性的文献,检索时间是数据平台创建日~2016年4月。运用Revman5.3统计学软件对纳入文献进行Meta分析。结果:共纳入文献10篇,纳入患者总数为803例。Meta分析结果显示,两组有效率比较,差异有统计学意义[OR(95%CI)=8.40(4.39,16.09),P0.01];两组瘙痒缓解率比较,差异有统计学意义[OR(95%CI)=6.56(3.19,13.50),P0.01];两组不良反应发生率比较,差异无统计学意义[OR(95%CI)=1.02(0.61,1.73),P=0.93]。亚组分析显示:口服有效率比较,差异有统计学意义[OR(95%CI)=9.10(3.24,25.56),P0.01];静脉有效率比较,差异有统计学意义[OR(95%CI)=7.98(3.46,18.39),P0.01]。结论:与单纯窄谱UVB治疗相比,复方甘草酸苷联合窄谱UVB治疗玫瑰糠疹的有效率及瘙痒缓解率更高,无严重的不良反应。
[Abstract]:Objective: to evaluate the efficacy and safety of compound glycyrrhizin combined with narrow band UVB in the treatment of pityriasis roseus. Methods: the literatures on the efficacy and safety of compound glycyrrhizin combined with narrow spectrum UVB in treating pityriasis roseus were searched by computer in Pubmed,Cochrane library,Em BASE resource bank, China Zhiwang, Weipu resource platform and Wanfang data platform. The retrieval time is from the date of creation of the data platform to April 2016. Revman5.3 statistical software was used to analyze the included literature by Meta. Results: 10 articles were included and 803 patients were included. The results of Meta analysis showed that there was a significant difference between the two groups in effective rate [OR (95%CI) = 8.40 (4.39 卤16.09), P0.01]; There was significant difference in the relief rate of pruritus between the two groups [OR (95%CI) = 6.56 (3.19 ~ 13.50), P0.01]. There was no significant difference in the incidence of adverse reactions between the two groups [OR (95%CI) = 1. 02 (0. 61 卤1. 73), P < 0. 93]. Subgroup analysis showed that there was significant difference in oral response rate (OR (95%CI) = 9.10 (3.240.56), P0.01). The venous response rate was significantly different [OR (95%CI) = 7.98 (3.46 ~ 18.39), P0.01]. Conclusion: compared with narrow spectrum UVB, compound glycyrrhizin combined with narrow spectrum UVB is more effective and can relieve pruritus in patients with pityriasis roseus.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.64

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