1030例汉族儿童异位性皮炎患者临床特征与总IgE相关性研究
发布时间：2019-03-31 00:56
【摘要】：背景异位性皮炎(atopic dermatitis,AD)是一种慢性、炎症性、反复发作性疾病,好发于婴儿和儿童,常常伴有血清总IgE(tIgE)升高。关于tIgE水平与AD临床特征在中国汉族中的研究不多,本研究对1030例AD儿童血清tIgE与临床特征进行回顾性分析。 目的探讨儿童异位性皮炎(AD) tIgE与临床特征的相互关系。 方法采用调查表的形式收集2008年1月至2010年3月来自全国多家医院的1030例儿童AD患者,均符合Hanifin-Rajka诊断标准。所有患者均采用AllergyScreen过敏原定量检测系统检测血清tIgE,并采用统一的问卷调查对病人及家属进行临床流行病学调查。应用Epi info 6.0软件、SPSS10.0软件对资料进行统计学处理和分析,采用单样本Kolmogorov - Smirnov检验,卡方检验和非参数检验,探讨tIgE值与AD临床特征的相关性。 结果1030例患儿中,男性为634例,女性为396例,男女比例为1.6:1。病人的平均年龄为1.5(0.5,5)岁,平均发病年龄为2(1,4)月,平均病程为3(2,7)月。患者的当前年龄范围是36天～12岁,发病年龄的范围是2天～11岁。1030例AD患儿中,499(48.4%)例患儿伴有血清tIgE水平升高,928(90.1%)例为城市儿童。与tIgE水平正常的患儿相比,tIgE水平升高的患儿发病年龄大(P 0.001)。tIgE升高组的“混合型”AD的患病率明显高于正常组(P 0.001),伴有tIgE升高的患儿更易伴发哮喘(BA()P 0.001)和过敏性皮炎(AR)(P = 0.036),但两组在家族异位性病上差异无显著性(P 0.05)。根据Mann-Whitney检验,tIgE升高组的SCORAD评分和OSAAD评分明显高于正常组(P 0.001和P = 0.001);根据秩和检验,两组AD的严重程度差异有显著性(P 0.001),伴有tIgE升高的患儿重度AD的可能性更大。在Hanifin-Rajka诊断标准的23项次要体征中早期发病年龄(90.9%)、干燥(74.8%)和面部苍白/红斑(70.5%)最常见。对除了tIgE升高外其他的次要体征进行统计学分析,部分在tIgE升高组和tIgE正常组中差异有显著性(均P 0.05)。 结论通过tIgE与儿童AD临床特征之间的相关性分析,得出tIgE可能是导致儿童AD严重度及临床特征有差异的原因之一,从而进一步对疾病的诊断、治疗和预后提供线索。
[Abstract]:Background atopic dermatitis (atopic dermatitis,AD) is a chronic inflammatory recurrent paroxysmal disease that occurs in infants and children and is often associated with elevated serum total IgE (tIgE). There are few studies on the clinical characteristics of tIgE and AD in Chinese Han nationality. The serum tIgE and clinical characteristics of 1030 children with AD were retrospectively analyzed in this study. Objective to investigate the relationship between (AD) tIgE and clinical features in children with atopic dermatitis. Methods from January 2008 to March 2010, 1030 cases of children with AD from many hospitals in China were collected by questionnaire. All of them met the diagnostic criteria of Hanifin-Rajka. Serum tIgE, was detected by AllergyScreen allergen quantitative detection system in all patients and clinical epidemiological investigation of patients and their families was carried out by unified questionnaire survey. The data were statistically processed and analyzed by Epi info 6.0software and SPSS10.0 software. Single sample Kolmogorov-Smirnov test, chi-square test and nonparametric test were used to explore the correlation between tIgE value and clinical features of AD. Results of the 1030 children, 634 were male and 396 were female. The ratio of male to female was 1.6%. The mean age of the patients was 1.5 (0.5, 5) years old. The mean age of onset was 2 (1, 4) months, and the mean course of disease was 3 (2, 7) months. The current age range of the patients ranged from 36 days to 12 years, and the age of onset ranged from 2 days to 11 years. Of the 1030 children with AD, 499 (48.4%) were accompanied by elevated serum tIgE levels, and 928 (90.1%) were urban children. Compared with the children with normal tIgE level, the children with elevated tIgE level had older onset age (P 0.001). The prevalence of "mixed" AD in the group with elevated tige level was significantly higher than that in the normal group (P 0.001). Children with elevated tIgE were more likely to have asthma (BA () P 0.001 (P 0.05) and allergic dermatitis (AR) (P = 0.036), but there was no significant difference in family ectopic venereal disease between the two groups (P 0.05). According to the Mann-Whitney test, the SCORAD score and OSAAD score in the tIgE elevation group were significantly higher than those in the normal group (P 0.001 and P = 0.001). According to the rank sum test, there was a significant difference in the severity of AD between the two groups (P 0.001). The children with elevated tIgE were more likely to have severe AD. The early onset age (90.9%), dry (74.8%) and pale / erythema (70.5%) were the most common of the 23 secondary signs of Hanifin-Rajka. In addition to the increase of tIgE, other secondary signs were statistically analyzed, and some of them were significantly different between the tIgE elevated group and the normal tIgE group (all P 0.05). Conclusion by analyzing the correlation between tIgE and clinical features of children with AD, it can be concluded that tIgE may be one of the reasons for the difference of severity and clinical features of AD in children, so as to provide clues for the diagnosis, treatment and prognosis of the disease.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.29
本文编号：2450672
[Abstract]:Background atopic dermatitis (atopic dermatitis,AD) is a chronic inflammatory recurrent paroxysmal disease that occurs in infants and children and is often associated with elevated serum total IgE (tIgE). There are few studies on the clinical characteristics of tIgE and AD in Chinese Han nationality. The serum tIgE and clinical characteristics of 1030 children with AD were retrospectively analyzed in this study. Objective to investigate the relationship between (AD) tIgE and clinical features in children with atopic dermatitis. Methods from January 2008 to March 2010, 1030 cases of children with AD from many hospitals in China were collected by questionnaire. All of them met the diagnostic criteria of Hanifin-Rajka. Serum tIgE, was detected by AllergyScreen allergen quantitative detection system in all patients and clinical epidemiological investigation of patients and their families was carried out by unified questionnaire survey. The data were statistically processed and analyzed by Epi info 6.0software and SPSS10.0 software. Single sample Kolmogorov-Smirnov test, chi-square test and nonparametric test were used to explore the correlation between tIgE value and clinical features of AD. Results of the 1030 children, 634 were male and 396 were female. The ratio of male to female was 1.6%. The mean age of the patients was 1.5 (0.5, 5) years old. The mean age of onset was 2 (1, 4) months, and the mean course of disease was 3 (2, 7) months. The current age range of the patients ranged from 36 days to 12 years, and the age of onset ranged from 2 days to 11 years. Of the 1030 children with AD, 499 (48.4%) were accompanied by elevated serum tIgE levels, and 928 (90.1%) were urban children. Compared with the children with normal tIgE level, the children with elevated tIgE level had older onset age (P 0.001). The prevalence of "mixed" AD in the group with elevated tige level was significantly higher than that in the normal group (P 0.001). Children with elevated tIgE were more likely to have asthma (BA () P 0.001 (P 0.05) and allergic dermatitis (AR) (P = 0.036), but there was no significant difference in family ectopic venereal disease between the two groups (P 0.05). According to the Mann-Whitney test, the SCORAD score and OSAAD score in the tIgE elevation group were significantly higher than those in the normal group (P 0.001 and P = 0.001). According to the rank sum test, there was a significant difference in the severity of AD between the two groups (P 0.001). The children with elevated tIgE were more likely to have severe AD. The early onset age (90.9%), dry (74.8%) and pale / erythema (70.5%) were the most common of the 23 secondary signs of Hanifin-Rajka. In addition to the increase of tIgE, other secondary signs were statistically analyzed, and some of them were significantly different between the tIgE elevated group and the normal tIgE group (all P 0.05). Conclusion by analyzing the correlation between tIgE and clinical features of children with AD, it can be concluded that tIgE may be one of the reasons for the difference of severity and clinical features of AD in children, so as to provide clues for the diagnosis, treatment and prognosis of the disease.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.29
【引证文献】
相关期刊论文 前1条
1 张秀钦;程波;肖鹏;王菁;;某地区特应性皮炎患者过敏原检测分析[J];中国医药指南;2012年28期
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