不同海拔地区藏、汉族健康人脑血管反应性研究

发布时间：2018-01-28 08:57

本文关键词： 藏汉族不同海拔高度脑血管反应性一氧化氮内皮型一氧化氮合酶　出处：《中风与神经疾病杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨高海拔藏汉族及不同海拔汉族健康成年人脑血管反应性(cerebrovascular reactivity,CVR)的差异,以及血浆一氧化氮(nitric oxide,NO)和内皮型一氧化氮合酶(endothelial NOS,eNOS)对脑血管反应性可能的调节作用。方法选取世居青海果洛(海拔3800 m)健康藏族45人为高海拔藏族组;在当地生活10 y以上的健康汉族45人为高海拔汉族组;世居青海西宁(海拔2200米)健康汉族45人为中海拔汉族组;世居四川广汉(海拔450米)健康汉族45人为低海拔汉族组。采用经颅多普勒超声(Transcranial Doppler,TCD)评估研究人群CVR,用硝酸还原酶法和酶联免疫吸附法测定各组血浆NO和e NOS水平。结果 (1)世居高海拔藏族组CVR、血浆NO及eNOS含量与高海拔汉族组无显著差异(P0.05);(2)低海拔汉族组CVR、血浆NO及eNOS含量明显高于中海拔汉族组(P0.05);(3)中海拔汉族组CVR、血浆NO及eNOS含量明显高于高海拔汉族组(P0.05);(4)低海拔汉族组CVR、血浆NO及eNOS含量明显高于高海拔汉族组(P0.05);(5)随着海拔高度越高,汉族健康人CVR、血浆NO及eNOS含量也越下降(P0.05)。结论高海拔地区藏汉族之间脑血管反应性没有明显差异;不同海拔汉族健康人群之间脑血管反应性有明显差异,且随着海拔高度逐渐升高,脑血管反应性逐渐下降,血浆一氧化氮和内皮型一氧化氮合酶与脑血管反应性可能有一定相关性。
[Abstract]:Objective to investigate the difference of cerebrovascular reactivity (CVR) in healthy adults of Tibetan Han nationality and Han nationality at high altitude. And plasma nitric oxide nitric oxide (no) and endothelial nitric oxide synthase (NOS). Methods 45 healthy Tibetans living in Guoluo Qinghai (3800 m above sea level) were selected as the high altitude Tibetan group. 45 healthy Han people living in the area above 10 years were of high altitude Han nationality group. 45 healthy Han people living in Xining Qinghai Province (2200m above sea level) were of middle altitude Han group. Forty-five healthy Han people living in Guanghan, Sichuan Province (450m above sea level) were in the low altitude Han nationality group. Transcranial Doppler was used by transcranial Doppler ultrasound. The plasma levels of no and e NOS were measured by nitrate reductase method and enzyme linked immunosorbent assay (Elisa). There was no significant difference in plasma no and eNOS levels between the Han nationality group and the Han nationality group at high altitude (P 0.05). (2) the levels of plasma no and eNOS in the Han nationality at low altitude were significantly higher than those in the Han nationality at middle altitude. (3) the levels of plasma no and eNOS in the Han nationality at middle altitude were significantly higher than those in the Han nationality at high altitude (P 0.05). (4) the levels of no and eNOS in low altitude Han nationality group were significantly higher than those in high altitude Han nationality group (P 0.05). (5) with the increase of altitude, the contents of no and eNOS in plasma of healthy Han people also decreased (P 0.05). Conclusion there is no significant difference in cerebral vascular reactivity between Tibetan and Han nationality at high altitude. There were significant differences in cerebral vascular reactivity among healthy Han people at different elevations, and the cerebral vascular reactivity decreased gradually with the elevation increasing. Plasma nitric oxide and endothelial nitric oxide synthase may be correlated with cerebral vascular reactivity.
【作者单位】：青海省人民医院神经内科;
【基金】：青海省自然科学基金项目(2013-Z-921) 青海省科技支撑计划项目(2014-NS-120-1)
【分类号】：R743
【正文快照】： 高原脑血管病作为严重威胁高原人群健康的疾病之一,对其特殊病因、发病机制的研究,有助于解决缺氧性疾病的核心问题和关键环节,对疾病的防治有着重要的指导意义[1]。脑血管反应性(cerebro-vascular reactivity,CVR)是指脑血管当受到各种生理或病理因素刺激时,脑血管通过舒张以

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