脉血康胶囊对血瘀型偏头痛患者血浆溶血磷脂酸和内皮素-1水平的影响

发布时间：2018-02-21 00:30

本文关键词： 脉血康胶囊偏头痛血瘀型溶血磷脂酸内皮素-1　出处：《福建中医药大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：本课题通过临床研究血瘀型偏头痛患者血浆溶血磷脂酸(LPA)及内皮素(ET-1)水平,从而对偏头痛的机制进行进一步的探讨。通过急性发作期给予中药脉血康胶囊干预治疗观察LPA及ET-1水平变化,试图寻找另一种适用于偏头痛急性期的中成用药。研究方法：本研究采用随机平行对照方法,入组80例急性发作血瘀型偏头痛(中度程度头痛)患者。按照随机数字表法分为常规治疗组(38例)和脉血康治疗组(42例)。常规治疗组方案：氟桂利嗪5mg qn；脉血康治疗组方案：氟桂利嗪5mg qn+脉血康胶囊(2粒／次、3次／日),两组患者均连续服药28天。两组患者分别在就诊次日、服药14天、28天进行头痛量表评分、头痛程度VAS评分、抽血检测血浆LPA和ET-1水平。测定同期健康人群LPA和ET-120例作为正常对照组。结果：1.血瘀型偏头痛急性期患者血浆LPA及ET-1水平较正常对照组升高,差异有统计学意义(P0.05)。2.血瘀型偏头痛急性发作3天内LPA及ET-1水平较发作14天、28天后明显升高,差异有统计学意义(P0.05)。.3.急性发作期脉血康治疗组较常规治疗组临床疗效更好,头痛量表评分及头痛程度VAS评分下降更显著,差异有统计学意义(P0.05)。4.两组患者14天、28天时血浆LPA及ET-1,与治疗前比较均有下降,脉血康治疗组与常规治疗组比较降低更明显,差异均有统计学意义(P0.05),14天时两组患者血浆LPA仍高于正常对照组,与正常对照组比较差异有统计学意义(P0.05)；14天时脉血康治疗组血浆ET-1与正常对照组比较差异无统计学意义(p0.05),常规治疗组ET-1仍高于正常对照组,与正常对照组比较差异有统计学意义(P0.05)。两组患者服药28天后血浆LPA及ET-1水平均接近正常对照组,与正常对照组比较差异均无统计学意义(P0.05)。结论：1.血瘀型偏头痛急性期患者血浆溶血磷脂酸及内皮素-1水平较正常人群高。2.脉血康胶囊能降低血瘀型偏头痛急性发作期患者头痛量表评分及头痛程度评分。3.脉血康胶囊能降低血瘀型偏头痛急性发作期患者血浆LPA及ET-1水平。4.血瘀型偏头痛急性发作期患者LPA与ET-1水平同时升高,提示偏头痛急性发作期患者可能同时存在血小板活化、内皮损伤及血管舒缩障碍。
[Abstract]:Objective: to study the levels of plasma lysophosphatidic acid (LPA) and endothelin (et 1) in patients with migraine with blood stasis type. Therefore, the mechanism of migraine was further discussed. The changes of LPA and ET-1 levels were observed by the intervention therapy of Mai Xue Kang capsule during acute attack, in order to find another medium medicine suitable for migraine acute phase. Methods: a randomized parallel control method was used in this study. 80 patients with acute attack of blood stasis type migraine (moderate degree headache) were divided into routine treatment group (n = 38) and mai xuekang treatment group (n = 42). Routine treatment group: flunarizine 5 mg QN; mai xue Kang. The treatment group was treated with flunarizine 5 mg QN Mai Xue Kang capsule 2 capsules / time 3 times a day. The patients in both groups were treated continuously for 28 days. The scores of headache scale, VAS score of headache degree, plasma LPA and ET-1 levels were measured in 14 days and 28 days after taking medicine, and LPA and ET-120 were measured as normal control group in the same period. Results 1. The levels of plasma LPA and ET-1 in patients with acute migraine of blood stasis type were significantly higher than those in the control group (P 0.05). The levels of LPA and ET-1 in acute migraine of blood stasis type were significantly higher than those in 14 days and 28 days after onset of migraine with blood stasis. The difference was statistically significant (P 0.05) .3.The clinical efficacy of Mai Xue Kang group was better than that of routine treatment group, and the score of headache scale and the VAS score of headache degree decreased more significantly. There was a significant difference in plasma LPA and ET-1 between the two groups at 14 days and 28 days after treatment. The plasma LPA and ET-1 levels in the two groups were significantly lower than those before treatment, and those in the Maoxuekang group were significantly lower than those in the routine treatment group. There were significant differences in plasma LPA between the two groups on the 14th day of P0.05, and the plasma LPA in the two groups was still higher than that in the normal control group. There was no significant difference in plasma ET-1 between the control group and the normal control group at 14 days after treatment. The ET-1 of the routine treatment group was still higher than that of the normal control group. The plasma LPA and ET-1 levels in the two groups were similar to those in the normal control group after 28 days, but there was no significant difference between the two groups. Conclusion 1.The plasma levels of lysophosphatidic acid and endothelin-1 in patients with acute migraine of blood stasis type are higher than those in normal people. Meisuekang capsule can reduce the score of headache scale and headache degree in patients with acute migraine of blood stasis type. 3.Mai Xue Kang capsule can reduce the levels of plasma LPA and ET-1 in patients with migraine of blood stasis type. 4. The levels of LPA and ET-1 in patients with acute attack of migraine of blood stasis type increased at the same time. The results suggest that there may be platelet activation, endothelial injury and vasomotor dysfunction in patients with migraine during acute attack.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R747.2

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