肾小球滤过率和扩大的血管周围间隙在缺血性卒中患者预后评价中的价值

发布时间：2018-02-24 10:46

本文关键词： 卒中脑缺血肾小球滤过率预后　出处：《中国现代神经疾病杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨缺血性卒中患者肾小球滤过率与扩大的血管周围间隙在预后评价中的价值。方法共171例急性缺血性卒中患者按照改良Rankin量表(m RS)评分分为预后不良组(88例)和预后良好组(83例),检测血清肌酐水平并计算肾小球滤过率,计数基底节区和半卵圆中心扩大的血管周围间隙数量并评分,测量基底节区和半卵圆中心扩大的血管周围间隙直径并分级。结果与对照组相比,预后不良组和预后良好组扩大的血管周围间隙评分(P=0.002,0.000)和血清肌酐水平(P=0.000,0.000)均升高、肾小球滤过率降低(P=0.001,0.000),预后不良组扩大的血管周围间隙评分(P=0.001)和血清肌酐水平(P=0.034)高于预后良好组、肾小球滤过率低于预后良好组(P=0.000)。扩大的血管周围间隙分级0级17例、1级89例、2级43例、3级22例,3级组和2级组血清肌酐水平高于1级组和0级组(均P=0.000)、肾小球滤过率低于1级组和0级组(均P=0.000)。相关分析显示,预后不良组和预后良好组患者m RS评分与扩大的血管周围间隙评分呈正相关(r=0.350,P=0.033;r=0.481,P=0.036),与肾小球滤过率呈负相关(r=-0.447,P=0.018;r=-0.553,P=0.002)。结论缺血性卒中患者m RS评分与扩大的血管周围间隙评分呈正相关、与肾小球滤过率呈负相关,二者均可作为缺血性卒中患者预后的预测指标。
[Abstract]:Objective to investigate the value of glomerular filtration rate (GFR) and enlarged perivascular space in evaluating prognosis in patients with ischemic stroke. Methods 171 patients with acute ischemic stroke were divided into poor prognosis group according to modified Rankin scale / mRSs. Serum creatinine level and glomerular filtration rate were measured in 83 patients with good prognosis. Count and score the number of perivascular spaces in basal ganglia and hemi-oval center, measure the diameter and grade of perivascular space in basal ganglia and hemi-oval center. In the poor prognosis group and the good prognosis group, the enlarged perivascular space score (P0. 002 0. 000) and the serum creatinine level (P 0. 000 ~ 0. 000) were increased, the glomerular filtration rate was decreased, and the P0. 001) and serum creatinine levels in the poor prognosis group were higher than those in the good prognosis group (P 0. 001) and the serum creatinine level (P 0. 034). The glomerular filtration rate was lower than that in the prognostic group (P = 0.000). The serum creatinine level in the enlarged perivascular space grade 0, grade 0, grade 1, grade 1, grade 1, grade 89, grade 3, grade 3, grade 22, grade 3, group 2, group 2, were higher than those in the group of grade 1 and grade 0 (all P 0. 000, glomerular filtration). The overpass rate was lower than that of grade 1 group and grade 0 group (P0. 000%). Correlation analysis showed that, In the poor prognosis group and the good prognosis group, the Mrs score was positively correlated with the enlarged perivascular space score, and was negatively correlated with the glomerular filtration rate. Conclusion there was a positive correlation between the Mrs score and the enlarged perivascular space score in patients with ischemic stroke. There was a negative correlation between glomerular filtration rate and glomerular filtration rate, both of which could be used as predictors of prognosis in ischemic stroke patients.
【作者单位】：四川大学华西医院神经内科;汉中职业技术学院附属医院神经内科;
【基金】：国家自然科学基金资助项目(项目编号:81371283);国家自然科学基金资助项目(项目编号:81671146)~~
【分类号】：R743.3

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