2型糖尿病合并脑梗死与网膜素-1的相关性研究

发布时间：2018-02-28 12:24

本文关键词： 网膜素- 血清型糖尿病脑梗死糖脂代谢　出处：《实用临床医学》2014年02期 　论文类型：期刊论文

【摘要】：目的通过检测2型糖尿病、脑梗死非糖尿病和2型糖尿病合并脑梗死患者血清网膜素-1(Omentin-1)水平的变化,探讨Omentin-1与2型糖尿病合并脑梗死的相关关系。方法采用双抗体夹心酶联免疫吸附试验法检测33例2型糖尿病患者(2型糖尿病组)、30例2型糖尿病合并脑梗死患者(2型糖尿病合并脑梗死组)、33例脑梗死非糖尿病患者(脑梗死非糖尿病组)和30例健康体检者(健康对照组)血清Omentin-1水平,计算体质量指数(BMI),检测血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)]、糖化血红蛋白(HbAlc)和空腹血糖(FPG)等生化指标。分析血清Omentin-1水平的变化及其与HbAlc和FPG的相关性。结果与健康对照组比较,2型糖尿病组、2型糖尿病合并脑梗死组的HbAlc和FPG水平均明显升高、血清Omentin-1水平明显降低(P0.05或P0.01),2型糖尿病组的TC水平明显升高、2型糖尿病合并脑梗死组的TG水平明显升高(P0.01),脑梗死非糖尿病组血清Omentin-1水平明显降低(P0.05);与2型糖尿病合并脑梗死组比较,2型糖尿病组、脑梗死非糖尿病组的HbAlc水平均明显降低(均P0.05);与脑梗死非糖尿病组比较,2型糖尿病组、2型糖尿病合并脑梗死组的HbAlc、FPG水平均明显升高(均P0.01),2型糖尿病合并脑梗死组血清Omentin-1水平明显降低(P0.05)。相关性分析结果显示,2型糖尿病合并脑梗死组血清Omentin-1水平与HbAlc、FPG水平均呈负相关(r=-0.264、-0.285,均P0.01)。结论血清Omentin-1水平与糖脂代谢相关,参与了脑梗死和糖尿病的病理生理过程,可能在2型糖尿病合并脑梗死的发生发展中起一定的作用。
[Abstract]:Objective to investigate the changes of serum omentin-1 in patients with type 2 diabetes mellitus, cerebral infarction non-diabetes mellitus and type 2 diabetes mellitus with cerebral infarction. To investigate the relationship between Omentin-1 and type 2 diabetes mellitus complicated with cerebral infarction. Methods the double antibody sandwich enzyme linked immunosorbent assay (Elisa) was used to detect 30 patients with type 2 diabetes mellitus complicated with cerebral infarction in 33 patients with type 2 diabetes mellitus and 30 patients with type 2 diabetes mellitus complicated with cerebral infarction. The serum levels of Omentin-1 were measured in 33 patients with cerebral infarction and 30 healthy persons (healthy control group) in type type diabetes mellitus complicated with cerebral infarction group, and 30 healthy controls, and 33 patients with cerebral infarction without diabetes mellitus (non-diabetic group) and 30 healthy persons (healthy control group). Body mass index (BMI) was calculated to detect serum lipids (TC, TG, LDL-C and HDL-C), HbAlc (glycosylated hemoglobin) and FBG (fasting blood glucose). Results the levels of HbAlc and FPG in type 2 diabetic patients with cerebral infarction were significantly higher than those in healthy controls. The level of serum Omentin-1 was significantly decreased in patients with type 2 diabetes mellitus (P 0.05) or in type 2 diabetes mellitus (P 0.01). The level of TG in patients with type 2 diabetes complicated with cerebral infarction was significantly higher than that in patients with cerebral infarction. The level of serum Omentin-1 in non-diabetic patients with cerebral infarction was significantly lower than that in patients with type 2 diabetes mellitus (P 0.05), and it was associated with type 2 diabetes mellitus. Patients with cerebral infarction were compared with those with type 2 diabetes, The level of HbAlc in type 2 diabetic patients with cerebral infarction was significantly higher than that in type 2 diabetes patients with cerebral infarction (P0.01), and the level of HbAlc FPG in type 2 diabetes patients with cerebral infarction was significantly higher than that in type 2 diabetic patients with cerebral infarction (P0.01). The results of correlation analysis showed that there was a negative correlation between serum Omentin-1 level and HbAlcfg level in patients with type 2 diabetes mellitus complicated with cerebral infarction. Conclusion the serum Omentin-1 level is correlated with glucose and lipid metabolism in patients with type 2 diabetes mellitus and cerebral infarction, and the level of serum Omentin-1 is significantly lower than that of P0.050.Conclusion there is a negative correlation between serum Omentin-1 level and HbAlctrol FPG level in patients with type 2 diabetes mellitus complicated with cerebral infarction. It is involved in the pathophysiological process of cerebral infarction and diabetes, and may play a role in the occurrence and development of type 2 diabetes mellitus with cerebral infarction.
【作者单位】：石河子大学第一附属医院神经内科;石河子大学医学院神经病学教研室;
【分类号】：R743;R587.1

【参考文献】