新生儿缺氧缺血性脑病与血管内皮生长因子水平的临床分析

发布时间：2018-03-11 18:34

本文选题：新生儿缺氧缺血性脑病　切入点：血管内皮生长因子水平　出处：《中外医疗》2016年32期 　论文类型：期刊论文

【摘要】：目的分析新生儿缺氧缺血性脑病(HIE)与血管内皮生长因子水平的相关性。方法将符合纳入标准的2015年1月—2016年1月期间进入该院的60例HIE足月新生儿作为实验组,将无神经系统疾病的60名足月新生儿作为对照组,比较两组在出生后24 h、7 d、10 d血浆内皮生长因素、神经元特异性烯醇化酶,比较两组出生后脑脊液内皮生长因子、神经元特异性烯醇化酶。结果实验组的NSE值在24 h、7 d、10 d分别为(19.43±7.03)、(15.06±3.01)、(10.97±2.59),明显高于对照组在24 h、7 d、10 d的NSE值(9.38±2.05)、(9.29±2.25)、(9.33±2.17),实验组的VEGF值在24 h、7 d、10 d分别为(591.34±60.42)ng/L、(488.54±49.89)ng/L、(449.24±67.37)ng/L,明显高于对照组在24 h、7 d、10 d的VEGF值(268.51±16.94)ng/L、(270.33±17.84)ng/L、(269.59±18.43)ng/L。对脑脊液的VEGF、NSE进行对比发现,实验组分别为(14.08±0.78)ng/L、(19.33±4.98)明显高于对照组(10.03±1.26)ng/L、(10.98±2.73),差异具有统计学意义(P0.01)。结论血管内皮生长因子能够作为新生儿HIE疾病的诊断、预后判断的重要指标。
[Abstract]:Objective to analyze the correlation between HIEs and vascular endothelial growth factor (VEGF) levels in neonates with hypoxic-ischemic encephalopathy (HIE). Methods 60 HIE full-term neonates who entered the hospital from January 2015 to January 2016 were selected as experimental group. 60 full-term newborns without nervous system disease were used as control group. Plasma endothelial growth factors and neuron-specific enolase were compared at 24 hours and 7 days after birth, and cerebrospinal fluid endothelial growth factors were compared between the two groups. Results the NSE values of the experimental group were 19.43 卤7.03 卤7.03 卤15.06 卤3.01 and 10.97 卤2.59 respectively, which were significantly higher than that of the control group at 24 hours and 7 days, 9.38 卤2.05, 9.29 卤2.25, 9.33 卤2.17, respectively. The VEGF values of the experimental group were 591.34 卤60.42ng / L, 488.54 卤49.89ngL / L respectively, which were significantly higher than those of the control group at 24 h / 7 / 10 day, respectively, and were significantly higher than those in the control group (P / L = 449.24 卤67.37ngL / L). The VEGF values of the experimental group were 591.34 卤60.42ngLngL / L = 488.54 卤49.89ngL / L = 449.24 卤67.37ngL / L, respectively. D's VEGF value was 268.51 卤16.94 ng / L, 270.33 卤17.84 ng / L, 269.59 卤18.43 ng / L, respectively. The experimental group was 14.08 卤0.78 ng / L (19.33 卤4.98) significantly higher than the control group (10.03 卤1.26 ng / L, 10.98 卤2.73). Conclusion Vascular endothelial growth factor can be used as an important index in the diagnosis and prognosis of neonatal HIE disease.
【作者单位】：南京鼓楼医院集团宿迁市人民医院儿科中心;
【分类号】：R742

【相似文献】