非酮症高血糖偏侧舞蹈症3例临床特征分析并文献复习

发布时间：2018-03-21 13:47

本文选题：糖尿病　切入点：非酮症高血糖　出处：《中南大学学报(医学版)》2017年11期 　论文类型：期刊论文

【摘要】：目的:探讨非酮症高血糖偏侧舞蹈症(hemichorea associated with non-ketotic hyperglycemia,HC-NH)的临床特点、影像学表现、治疗现状以及发病机制。方法:回顾性分析中南大学湘雅医院收治的3例HC-NH患者的临床资料,并复习相关文献。结果:HC-NH以老年女性多见,表现为急性起病的偏侧舞蹈症状,血糖升高、尿糖阳性及尿酮体阴性;影像学特点包括病变肢体对侧基底核区CT高密度灶,MRI T1加权像(T1 weighted imaging,T1WI)高信号灶;治疗上以控制血糖为主,可加用多巴胺受体拮抗药或镇静药物控制舞蹈症状,预后良好。结论:患者出现非酮症性血糖升高、MRI表现为基底核区T1WI高信号及偏侧舞蹈症状提示HC-NH,控制血糖及给予多巴胺受体拮抗药或镇静药物治疗可改善患者症状。
[Abstract]:Objective: to investigate the clinical features, imaging manifestations, treatment status and pathogenesis of hemichorea associated with non-ketotic hyperglycemia HC-NH. Methods: the clinical data of 3 cases of HC-NH in Xiangya Hospital of Central South University were retrospectively analyzed. Results the elderly women were more common than the old women. The symptoms of hemiplegia, hyperglycemia, positive urine glucose and negative urethral ketone body were found in the elderly women. The imaging features included CT high-density lesions in the contralateral basal nucleus of the extremities (T1-weighted T1 weighted imaging T1WI), the treatment of which was dominated by the control of blood glucose, and the use of dopamine receptor antagonists or sedatives to control dance symptoms. Conclusion: the high signal intensity of T1WI and the unilateral dance symptoms in the basal nucleus region suggest that HC-NH, blood glucose control and dopamine receptor antagonist or sedative therapy can improve the symptoms of patients with non-ketogenic hyperglycemia.
【作者单位】：中南大学湘雅医院老年病学神经内科;
【基金】：国家自然科学基金青年科学基金(81401060)~~
【分类号】：R742.2

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