青少年肌阵挛癫痫丘脑——皮质网络的磁共振波谱研究进展

发布时间：2018-03-22 04:09

本文选题：青少年　切入点：癫痫　出处：《中国医学影像技术》2017年06期 　论文类型：期刊论文

【摘要】：青少年肌阵挛癫痫是一种特发性全面性癫痫综合征,对其诊断主要依靠病史、临床症状和脑电图,常规影像学检查未见脑内器质性病变。MRS可无创地定量测定脑内神经代谢物浓度,评估患者大脑代谢改变。目前,丘脑—皮质网络功能障碍是本病的研究热点,该网络中存在神经代谢物浓度改变以及神经递质谷氨酸和γ-氨基丁酸代谢失衡。而癫痫的发病与脑内兴奋性和抑制性氨基酸的比例失衡有关,且癫痫发作可引起神经元损伤,导致神经元相关代谢产物浓度改变。本文将物质代谢、神经结构和功能相结合,对青少年肌阵挛癫痫患者的磁共振波谱研究进行综述。
[Abstract]:Juvenile myoclonic epilepsy is an idiopathic generalized epilepsy syndrome, the diagnosis mainly depends on medical history, clinical symptoms and EEG, conventional imaging examinations showed no pathological changes in the brain.MRS is a noninvasive determination of metabolite concentration in brain nerve quantitatively, change the evaluation of patients with brain metabolism. At present, thalamocortical network dysfunction is the research focus of this disease, there are nerve metabolic changes and neurotransmitter glutamate and GABA metabolic imbalance in the network. And the incidence of epilepsy and brain excitatory and inhibitory amino acid imbalance, and seizures can cause neuronal damage, leading to neuronal related metabolites. This paper will change metabolism, nerve structure and function combination, carries on the summary to the study of magnetic resonance spectroscopy in juvenile myoclonic epilepsy.

【作者单位】：南京大学医学院;南京大学医学院附属鼓楼医院医学影像科;
【基金】：国家自然科学基金青年基金(81301198、81300925)、国家自然科学基金面上项目(81571040)
【分类号】：R445.2;R742.1

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