不同癫痫发作类型发作间期和发作后血清ATP ADP及AMP水解率的动态变化

发布时间：2018-04-04 20:12

  本文选题：癫痫发作　切入点：三磷酸腺苷二磷酸水解酶　出处：《中国实用神经疾病杂志》2016年24期

【摘要】：目的探讨不同癫痫发作类型发作间期和发作后血清ATP、ADP和AMP水解率的变化。方法选择2014-03—2015-12我院神经内科收治的癫痫患者65例(全面性发作组33例,复杂部分性发作组32例),收集同期在我院门诊进行常规体检的正常人员35例为健康对照组,采用紫外线吸收分光光度法,观察病例组癫痫发作后5、10、20、30、60min和10h时的ATP、ADP和AMP水解率变化情况,并与健康对照组比较;观察全面性发作组和复杂部分性发作组癫痫发作后5、10、20、30、60min和10h时的ATP、ADP和AMP水解率变化情况,并进行比较;采用SPSS 21.0版本统计学软件进行数据处理。结果病例组发作间期ATP水解率、ADP水解率、AMP水解率与对照组比较差异无统计学意义(P0.05);发作后5min时ATP水解率、ADP水解率、AMP水解率均明显升高,其中ATP水解率在发作后20min达峰值,之后逐渐下降,至发作后10h恢复至发作间期水平;ADP水解率、AMP水解率在发作后5min达峰值,随后逐渐下降,至发作后60min即恢复至发作间期水平;全面性发作组和部分性发作组相比,癫痫发作后5min,20min血清ATP水解率、ADP水解率、AMP水解率升高更为显著(P0.05)。结论癫痫发作后腺苷酸水解率明显升高,全面性发作患者与部分性发作患者相比,腺苷酸水解率升高更为明显。
[Abstract]:Objective to investigate the changes of ADP and AMP hydrolysis rate in serum during and after different seizure types.Methods Sixty-five epileptic patients (33 patients with comprehensive seizure group and 32 patients with complex partial seizure group) were selected from neurology department of our hospital from 2014-03-2015-12. 35 normal persons who underwent routine physical examination in outpatient department of our hospital at the same time were selected as healthy control group.Ultraviolet absorption spectrophotometry was used to observe the changes of ATP ADP and AMP hydrolysis rate at 30min and 10h after epileptic seizure in the case group, and the results were compared with those in the healthy control group.The changes of ATP ADP and AMP hydrolysis rate were observed and compared at 60 min and 10 h after seizure in patients with global seizure and complex partial seizure, and the data were processed by SPSS 21.0 version statistical software.Results there was no significant difference in ATP hydrolysis rate and ADP hydrolysis rate between the two groups compared with the control group (P 0.05), but the ATP hydrolysis rate and the ADP hydrolysis rate in the 5min group were significantly higher than those in the control group, and the ATP hydrolysis rate reached its peak value after the onset of 20min.Then decreased gradually, and recovered to the interictal level at 10 h after attack. The hydrolysis rate of 5min reached its peak value after attack, then gradually decreased, and 60min recovered to the interictal level after attack.The hydrolysis rate of serum ATP and the hydrolysis rate of AMP were significantly increased 5 min after seizure and 20 min after seizure (P 0.05).Conclusion the hydrolysis rate of adenylate in patients with generalized seizure was significantly higher than that in patients with partial seizures.
【作者单位】： 郑州大学附属中心医院;郑州大学第一附属医院;
【分类号】：R742.1
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本文编号：1711501