阿托伐他汀对大鼠颈动脉粥样硬化易损斑块及hs-CRP和MMP-9表达的影响

发布时间：2018-04-08 23:13

本文选题：颈动脉粥样硬化　切入点：阿托伐他汀　出处：《中风与神经疾病杂志》2016年04期

【摘要】：目的研究阿托伐他汀对大鼠颈内动脉粥样硬化易损斑块面积、数目及对基质金属蛋白酶9(MMP-9)表达和血清hs-CRP的影响。方法将48只健康雄性SD大鼠随机分为对照组、模型组、常规剂量组、强化剂量组,14 w后采血测量hs-CRP,光镜下观察颈内动脉粥硬化易损斑块病理学变化,计数易损斑块数目及面积,采用免疫组织化学法检测易损斑块中MMP-9的表达。结果与模型组相比,常规剂量组和强化剂量组易损斑块计数、面积大小、MMP-9表达均明显降低(P0.01),强化剂量组又低于常规剂量组(P0.05),强化剂量组和常规剂量组血清hs-CRP测定结果均明显低于模型组(P0.01),强化剂量组又低于常规剂量组(P0.05)。结论阿托伐他汀能够稳定及减少颈内动脉粥样硬化易损斑块的形成和进展,对血清hs-CRP及MMP-9的表达具有抑制作用,并且其抑制作用与剂量具有量效关系。
[Abstract]:Objective to investigate the effect of atorvastatin on rat carotid atherosclerosis plaque area, and the number of matrix metalloproteinase 9 (MMP-9) expression and serum hs-CRP. Methods 48 healthy male SD rats were randomly divided into control group, model group, the conventional dose group, supplement dosage group, 14 w after blood sampling measurement hs-CRP, under the light microscope observation of carotid atherosclerosis plaque pathological changes, count the number and area of plaque, vulnerable plaque in MMP-9 expression was detected by immunohistochemical method. Results compared with the model group, the conventional dose group and high dose group of vulnerable plaque count, size, expression of MMP-9 was significantly decreased (P0.01), strengthening dose group was lower than that of the conventional dose group (P0.05), high dose group and conventional dose group serum hs-CRP was significantly lower than that of model group (P0.01), high dose group and low dose group than the conventional (P0.05). Conclusion Atorvastatin can stabilize and reduce the formation and progression of vulnerable atherosclerotic plaques, and inhibit the expression of hs-CRP and MMP-9 in serum, and its inhibitory effect is dose related to dosage.

【作者单位】：郑州大学第二附属医院神经内科;首都医科大学附属北京天坛医院神经内科;
【基金】：河南省医学科技攻关计划项目(No.201303087)
【分类号】：R543.4

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