联合MRS及CTP观察尤瑞克林治疗大面积脑梗死的疗效研究

发布时间：2018-04-10 11:21

本文选题：大面积脑梗死 + 尤瑞克林　；参考：《中风与神经疾病杂志》2017年07期

【摘要】：目的联合磁共振波谱(Magnetic Resonance Spectrum,MRS)分析及CT灌注成像(CT perfusion imaging,CTP)观察尤瑞克林对大面积脑梗死患者的临床疗效。方法将62例大面积脑梗死患者,随机分为尤瑞克林治疗组(试验组)和常规治疗组(对照组)各31例;两组患者均给予常规内科处理(包括合并高血压、糖尿病、心脏病等的一般药物治疗),试验组在常规治疗的基础上加用尤瑞克林治疗。采用NIHSS评分评价治疗前及治疗后14 d患者神经功能缺损变化。采用Barthel指数记分法评定日常生活活动能力(ADL)记录患者治疗前及治疗后14 d、30 d、90 d的评分。用MRS分析患者治疗前及治疗后14 d脑梗死组织代谢物N-乙酰天门冬氨酸(NAcetylpartate,NAA)、胆碱(Choline,Cho)、肌酸(Creatine,Cr)及乳酸(Lactate,Lac)的含量。用CTP分析治疗前及治疗后14 d梗死区rCBF、rCBV、rTTP和rMTT指标。结果治疗前两组患者NIHSS评分、Barthel指数、hs-CRP水平、MRS及CTR的各检测指标的差异无显著性意义(P0.05);治疗后,发现各组患者上述指标均较治疗前明显改善(P0.05);但尤瑞克林组的改善幅度尤为显著,两组间差异均具有显著性意义(P0.05)。结论尤瑞克林可明显改善大面积脑梗死患者的神经功能缺损和日常生活能力,作用机制可能是通过改善梗死区的微循环和神经细胞的代谢。
[Abstract]:Objective to evaluate the clinical efficacy of eurekline in the treatment of large area cerebral infarction with magnetic Resonance spectroscopy (MRS) analysis and CT perfusion imaging (CT perfusion imaging).Methods Sixty-two patients with large area cerebral infarction were randomly divided into two groups: Eucrine treatment group (experimental group) and routine treatment group (control group), 31 patients in each group were treated with routine medical treatment (including hypertension, diabetes mellitus).Heart disease and other general drug therapy, the trial group on the basis of routine treatment with eucrine treatment.NIHSS score was used to evaluate the changes of neurologic function before treatment and 14 days after treatment.Activities of daily living (ADL) were evaluated by Barthel index scoring method. The scores of patients with ADL were recorded before treatment and 30 days after treatment.The contents of NAcetylpartateNAcetylpartateNAcetylpartate, CholineChoa, Creatine Cr-lc and Lactate Lacs were determined by MRS before and 14 days after treatment in patients with cerebral infarction.CTP was used to analyze rTTP and rMTT in infarct area before and 14 days after treatment.There was significant difference between the two groups (P 0.05).Conclusion Uriklin can obviously improve the neurological function defect and daily living ability of patients with large area cerebral infarction, and the mechanism may be by improving the microcirculation and the metabolism of nerve cells in the infarcted area.
【作者单位】：深圳市第二人民医院深圳大学附属第一医院神经内科;
【分类号】：R743.3

【参考文献】