伴有典型失神发作的特发性全面性癫痫的VBM研究

发布时间：2018-04-21 18:49

本文选题：失神发作 + 特发性全面性癫痫　；参考：《新乡医学院》2014年硕士论文

【摘要】：背景特发性全面性癫痫(Idiopathic Generalized Epilepsy, IGE)是一组癫痫综合征的统称,伴有典型失神发作的IGE是较特殊的一类疾病,突出的特点是突发突止的意识障碍,表现为突然停止正在进行的动作,旁人呼叫不可应答,持续时间数秒至数十秒不等,之后继续发作前正在进行的动作,脑电图极具特征性,表现为双侧对称同步的3Hz棘慢波。基于体素的形态测量学分析(voxel-based morphometry, VBM)是一种磁共振的结构分析法,可观察脑组织的细微改变,伴有典型失神发作的IGE的脑组织改变有何特点,一直没有确切的答案。目的观察伴有典型失神发作的特发性全面性癫痫患者脑灰质体积改变有何特点。方法收集9例常规头颅磁共振无异常的伴有典型失神发作的IGE患者和16例年龄、性别组成相匹配的正常志愿者,使用3.0T磁共振进行全脑结构(3D)扫描,采用VBM方法对脑灰质体积进行分析,观察其灰质体积改变有何特点。结果与正常对照组相比,伴有典型失神发作的IGE患者存在广泛的脑灰质体积减小,包括以下13个区域：右侧额叶直回、左侧额叶直回、右侧距状回/楔叶/舌回/枕中回/枕下回、左侧枕叶舌回/枕下回、左侧颞中回/颞上回、左侧枕下回/舌回、右侧枕叶舌回、左侧枕中回、右侧枕中回/枕上回/颞中回、右侧楔前叶/楔叶、右侧顶上小叶、右侧中央前回、右侧额上回/旁中央小叶/补充运动区,未发现灰质体积增大的脑区。结论伴有典型失神发作的IGE患者存在广泛的脑灰质体积减小,其中以枕叶最为显著。
[Abstract]:Background Idiopathic Generalized Epilepsys (ige) is a group of epilepsy syndromes. IGE with typical apnesia is a special kind of disease, which is characterized by sudden and sudden disturbance of consciousness. The call can not be answered and lasts from several seconds to tens of seconds. After that, the EEG is characterized by bilateral symmetrical synchronous 3Hz spike and slow wave. Morphometric analysis based on voxel-based morphometry (VBM) is a structural analysis of magnetic resonance, which can observe the subtle changes of brain tissue and the characteristics of brain tissue changes in IGE with typical aphasia. There is no definite answer. Purpose To observe the characteristics of gray matter volume changes in idiopathic comprehensive epilepsy with typical aphasia. Method A total of 9 IGE patients with typical aphasia and 16 normal volunteers with matched age and sex were examined with 3.0T MRI. The changes of gray matter volume were analyzed by VBM method. Result Compared with the normal control group, IGE patients with typical aphasia had extensive reduction of gray matter volume, including the following 13 regions: right frontal gyrus, left frontal gyrus, right distal gyrus / cuneiform gyrus / lingual gyrus / middle occipital gyrus / suboccipital gyrus. Left occipital gyrus / inferior occipital gyrus, left middle temporal / superior temporal gyrus, left inferior occipital / lingual gyrus, right occipital lobe lingual gyrus, left occipital middle gyrus, right middle occipital / superior occipital / middle temporal gyrus, right anterior cuneate / cuneate lobe, right superior parietal lobule, In the right precentral gyrus, right superior frontal gyrus / paraspinal central lobule / supplementary motor area, no enlarged gray matter area was found. Conclusion extensive reduction of gray matter volume was found in IGE patients with typical aphasia, especially in occipital lobe.
【学位授予单位】：新乡医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.1

【参考文献】