缺血性脑卒中患者颈动脉斑块性质与Cat S及Cys C的相关性

发布时间：2018-04-26 08:30

本文选题：组织蛋白酶S + 胱抑素C　；参考：《重庆医学》2017年31期

【摘要】：目的探讨缺血性脑卒中患者血清组织蛋白酶S(Cat S)与胱抑素C(Cys C)表达水平与颈动脉斑块性质的关系。方法 336例动脉粥样硬化性脑梗死患者,根据颈部血管超声分为稳定斑块组与不稳定斑块组;同期114例健康体检者为对照组。所有入组者空腹采血检测血清Cat S及Cys C。结果两组患者血清Cat S、Cys C及二者的比值(Cat S/Cys C)差异均有统计学意义(P0.05);且脑梗死患者不稳定斑块组血清Cat S较稳定斑块组增高,而血清Cys C水平较稳定斑块组降低,血清Cat S分别为(75.33±15.44)、(60.13±18.54)pg/mL,血清Cys C分别为(0.72±0.63)、(0.92±0.54)mg/L,Cat S/Cys C分别为103.67±2.53、64.63±9.23,两组比较,差异均有统计学意义(P0.05);经Spearman相关分析,血清Cat S水平及Cat S/Cys C与缺血性脑卒中患者颈动脉不稳定斑块的存在呈明显的正相关性(r=0.498,P0.05;r=0.753,P0.01);而血清Cys C水平呈负相关性(r=-0.213,P0.05)。结论血清Cat S/Cys C水平与缺血性脑卒中患者颈动脉斑块性质存在一定的相关性,有可能成为预测颈动脉斑块性质的血清学指标。
[Abstract]:Objective to investigate the relationship between the expression of serum cathepsin S(Cat Sand cystatin C(Cys C and carotid plaque in patients with ischemic stroke. Methods 336 patients with atherosclerotic cerebral infarction were divided into stable plaque group and unstable plaque group according to cervical vascular ultrasound, and 114 healthy persons as control group. Serum Cat S and Cys C were detected by fasting blood sampling. Results there were significant differences between the two groups in the level of serum Cat Sj Cys C and the ratio of Cat S/Cys C (P 0.05), and the level of serum Cat S in the unstable plaque group was higher than that in the stable plaque group, while the serum Cys C level was lower in the unstable plaque group than in the stable plaque group. The serum Cat S was 60.13 卤18.54 g / mL, the serum Cys C was 0.72 卤0.63 卤0.54 mg / mL, respectively, and the S/Cys C was 103.67 卤2.53 卤6.63 卤9.23, respectively. There was significant difference between the two groups by Spearman correlation analysis, The levels of serum Cat S and Cat S/Cys C were positively correlated with the presence of unstable plaque in carotid artery of patients with ischemic stroke. Conclusion the level of serum Cat S/Cys C is correlated with the character of carotid plaques in patients with ischemic stroke, which may be a serological index to predict the nature of carotid plaques.
【作者单位】：河南省开封市中心医院神经内科;四川大学华西公共卫生学院;
【基金】：河南省医学科技攻关计划项目(201303204) 河南省开封市科技发展计划项目(1503073)
【分类号】：R743.3

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