多形性胶质母细胞瘤预后因素分析

发布时间：2018-05-01 12:37

本文选题：胶质母细胞瘤 + 多形性　；参考：《中国微侵袭神经外科杂志》2013年08期

【摘要】：目的探讨多形性胶质母细胞瘤(GBM)预后相关的临床因素。方法回顾性分析160例随访资料完整的GBM,采用Kaplan-Meier法计算生存率及进行单因素分析,Log-rank法进行生存率显著性检验,Cox比例风险回归模型作多因素分析。结果本组病人术后1年、2年、5年生存率分别是65.3%、34.1%、9.1%。单因素分析显示年龄、肿瘤切除程度、治疗方式是影响GBM生存率的因素。多因素分析显示年龄、肿瘤部位、肿瘤切除程度及治疗方式是与GBM预后相关的独立因素。结论年龄、肿瘤部位、肿瘤切除程度和治疗方式是影响GBM预后的主要因素,积极的手术治疗和规范化、个体化的综合治疗可有效提高GBM病人的生存率。
[Abstract]:Objective to investigate the prognostic factors of glioblastoma multiforme (GBM). Methods one hundred and sixty cases of GBM with complete follow-up data were analyzed retrospectively. The survival rate was calculated by Kaplan-Meier method and the survival rate was tested by univariate analysis Log-rank method. The Cox proportional risk regression model was used for multivariate analysis. Results the 1 year, 2 year and 5 year survival rates of these patients were 65.3% and 34.1%, respectively. Univariate analysis showed that age, tumor resection and treatment were the factors affecting GBM survival rate. Multivariate analysis showed that age, tumor location, degree of tumor resection and treatment were independent factors related to prognosis of GBM. Conclusion Age, tumor location, degree of tumor resection and treatment are the main factors that affect the prognosis of GBM. Active surgical treatment and standardized, individualized combined therapy can effectively improve the survival rate of GBM patients.
【作者单位】：贵阳市第二人民医院神经外科;首都医科大学附属北京天坛医院神经外科中心;广东同江医院神经外科;
【基金】：卫生行业科研专项基金(编号:200902004) 首都医学发展科研基金(编号:2009-1040)
【分类号】：R739.41

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