尤瑞克林联合阿司匹林对急性脑梗死患者血清学指标及临床疗效的影响

发布时间：2018-07-13 20:48

【摘要】：目的探讨尤瑞克林联合阿司匹林治疗急性脑梗死的作用机制。方法选取86例急性脑梗死患者,随机分为观察组(n=43)和对照组(n=43),在常规治疗基础上,观察组予尤瑞克林及阿司匹林治疗,对照组仅予阿司匹林,治疗后2周比较两组患者血液流变学、同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)、胱抑素(Cys)-C、白介素(IL)-6、神经功能缺损(NIHSS)及日常生活能力(ADL)等。结果观察组血清Hcy、hs-CRP、VEGF、Cys-C、IL-6、NIHSS、ADL均优于对照组(P0.05);观察组临床疗效明显比对照组高[95.35%(41/43)vs 74.42%(32/43)](P0.05)。结论在急性脑梗死患者中应用尤瑞克林联合阿司匹林效果显著,其内在机制可能和早期改善血清Hcy、hs-CRP、VEGF、Cys-C、IL-6的表达相关。
[Abstract]:Objective to investigate the mechanism of Urethrin combined with aspirin in the treatment of acute cerebral infarction. Methods Eighty-six patients with acute cerebral infarction were randomly divided into two groups: observation group (n = 43) and control group (n = 43). On the basis of routine treatment, the observation group was treated with eucrine and aspirin, while the control group was treated with aspirin only. Hemorheology, homocysteine (Hcy), Gao Min C-reactive protein (hs-CRP), vascular endothelial growth factor (VEGF-VEGF), cystatin (Cys) -C, interleukin-6 (IL-6), neurologic impairment (NIHSS) and activities of daily living (ADL) were compared between the two groups two weeks after treatment. Results the serum levels of Hcyhs-CRP- VEGFN Cys-Csil / NIHSSN ADL in the observation group were significantly higher than those in the control group (P0.05), and the clinical efficacy in the observation group was significantly higher than that in the control group [95.35% (41 / 43) vs 74.42% (32 / 43)] (P0.05). Conclusion Urethrin combined with aspirin is effective in patients with acute cerebral infarction, and its intrinsic mechanism may be related to the early improvement of serum Hcyhs-CRP VEGF Cys-Cn IL-6 expression.
【作者单位】：广东省东莞市第三人民医院神经内科;
【基金】：广东省东莞市医疗卫生科技计划一般项目(编号:2015105101081)
【分类号】：R743.3

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