颅内压近红外无损监测及临床应用基础研究
发布时间：2018-08-26 20:54
【摘要】：颅内压增高广泛出现于神经外科颅脑疾病患者的临床综合征中,严重威胁患者的生命健康。目前临床上缺乏一种安全有效,实现颅内压长时间床旁无损精准监测的技术。本文利用近红外技术组织穿透深度大、安全、易操作等优点,对脑水肿引起的颅内压变化开展长时间、连续的无损监测基础研究。论文的主要工作和创新点:1、根据不同类型的脑水肿,构建相应的脑水肿仿真模型。分别对单一型脑水肿模型和混合型脑水肿模型进行Monte Carlo仿真研究。仿真获得组织表面光通量和脑水肿程度间的关系,并确定成人脑组织近红外检测的最佳范围;2、采用明胶构建脑部仿体模型,依据单一型脑水肿仿真模型改变仿体模型组织参数,并监测仿体表面电压值。研究发现仿体表面电压随脑水肿程度变化的趋势与Monte Carlo仿真结果一致,验证了Monte Carlo仿真模型的可靠性;3、采用脂多糖试剂制作大鼠脑水肿模型,利用Codman颅内压监护仪和自制组织参数检测系统分别监测大鼠有创颅内压和微创约化散射系数,获得脑水肿情况下大鼠颅内压与脑组织约化散射系数的变化规律,构建相应的数学模型,完成大鼠模型的颅内压近红外检测实验;4、监测神经外科术后监护患者的有创颅内压和无损脑组织约化散射系数,构建约化散射系数和颅内压的数学模型。根据临床病人的颅内压精准测试结果完成近红外无损颅内压定标。研究结果表明:颅内压的变化规律和834 nm波长下约化散射系数的变化规律完全吻合,可采用834 nm波长的近红外光对成人脑水肿引起的颅内压变化进行有效监测。
[Abstract]:Increased intracranial pressure is widely seen in the clinical syndrome of neurosurgical patients with craniocerebral diseases, which seriously threatens the life and health of patients. At present, there is a lack of a safe and effective technique for accurate monitoring of intracranial pressure near the bed for a long time. Taking advantage of the advantages of deep penetration, safety and easy operation of near-infrared tissue, this paper has carried out a long and continuous nondestructive monitoring of intracranial pressure changes caused by brain edema. The main work and innovation point of this paper is: 1. According to different types of brain edema, the corresponding simulation model of brain edema is constructed. Single brain edema model and mixed brain edema model were simulated by Monte Carlo. The relationship between the luminous flux of tissue surface and the degree of brain edema was obtained by simulation, and the optimum range of near-infrared detection of adult brain tissue was determined. Gelatin was used to construct the model of brain mimic body, and the tissue parameters of the model were changed according to the simulation model of single type of brain edema. The surface voltage of the imitating body was monitored. It was found that the trend of surface voltage change with the degree of brain edema was consistent with that of Monte Carlo simulation. The reliability of Monte Carlo simulation model was verified. The rat brain edema model was made with lipopolysaccharide reagent. Intracranial pressure (ICP) and reduced scattering coefficient of brain tissue in rats were monitored by Codman intracranial pressure monitor and self-made tissue parameter detection system, respectively. The changes of intracranial pressure and reduced scattering coefficient of brain tissue in rats with cerebral edema were obtained. The corresponding mathematical model was constructed, and the experimental work of Intracranial pressure (ICP) near infrared detection in rat model was completed. The invasive intracranial pressure (ICP) and the reduced scattering coefficient of noninvasive brain tissue were monitored after neurosurgery, and the mathematical models of reduced ICP and ICP were constructed. The near infrared nondestructive intracranial pressure calibration was completed according to the accurate test results of intracranial pressure of clinical patients. The results show that the variation of intracranial pressure is in good agreement with that of reduced scattering coefficient at 834 nm wavelength. The change of intracranial pressure caused by brain edema in adults can be effectively monitored by near-infrared light at 834 nm wavelength.
【学位授予单位】：南京航空航天大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R741.04
本文编号：2206127
[Abstract]:Increased intracranial pressure is widely seen in the clinical syndrome of neurosurgical patients with craniocerebral diseases, which seriously threatens the life and health of patients. At present, there is a lack of a safe and effective technique for accurate monitoring of intracranial pressure near the bed for a long time. Taking advantage of the advantages of deep penetration, safety and easy operation of near-infrared tissue, this paper has carried out a long and continuous nondestructive monitoring of intracranial pressure changes caused by brain edema. The main work and innovation point of this paper is: 1. According to different types of brain edema, the corresponding simulation model of brain edema is constructed. Single brain edema model and mixed brain edema model were simulated by Monte Carlo. The relationship between the luminous flux of tissue surface and the degree of brain edema was obtained by simulation, and the optimum range of near-infrared detection of adult brain tissue was determined. Gelatin was used to construct the model of brain mimic body, and the tissue parameters of the model were changed according to the simulation model of single type of brain edema. The surface voltage of the imitating body was monitored. It was found that the trend of surface voltage change with the degree of brain edema was consistent with that of Monte Carlo simulation. The reliability of Monte Carlo simulation model was verified. The rat brain edema model was made with lipopolysaccharide reagent. Intracranial pressure (ICP) and reduced scattering coefficient of brain tissue in rats were monitored by Codman intracranial pressure monitor and self-made tissue parameter detection system, respectively. The changes of intracranial pressure and reduced scattering coefficient of brain tissue in rats with cerebral edema were obtained. The corresponding mathematical model was constructed, and the experimental work of Intracranial pressure (ICP) near infrared detection in rat model was completed. The invasive intracranial pressure (ICP) and the reduced scattering coefficient of noninvasive brain tissue were monitored after neurosurgery, and the mathematical models of reduced ICP and ICP were constructed. The near infrared nondestructive intracranial pressure calibration was completed according to the accurate test results of intracranial pressure of clinical patients. The results show that the variation of intracranial pressure is in good agreement with that of reduced scattering coefficient at 834 nm wavelength. The change of intracranial pressure caused by brain edema in adults can be effectively monitored by near-infrared light at 834 nm wavelength.
【学位授予单位】：南京航空航天大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R741.04
【参考文献】
相关期刊论文 前8条
1 李海燕;张静萍;伍国锋;;有创颅内压监测并发中枢神经系统感染的多因素分析[J];中华神经科杂志;2014年11期
2 钱志余;李韪韬;;功能近红外光谱技术(fNIRs)临床应用综述[J];生命科学仪器;2013年03期
3 张华;肖立;高燕飞;;重型颅脑损伤病人体位变化对颅内压及脑灌注压的影响[J];护理研究;2012年14期
4 胡亚玲;王海燕;;不同吸痰深度对重型颅脑损伤机械通气患者颅内压力的影响[J];中华护理杂志;2012年01期
5 戴丽娟;花国然;钱志余;;近红外漫反射光谱在脱水剂脱水作用中的应用研究[J];量子电子学报;2010年06期
6 傅妮娜;王红;张华山;;近红外荧光探针及其在生物分析中的应用进展[J];分析科学学报;2008年02期
7 李良成;张永顺;李忠红;;近红外脑血氧监测设备在临床中的应用[J];红外;2007年02期
8 林方,丁海曙,王峰,苏畅;用多层Monte-Carlo模型研究脑部光学无损检测的问题[J];光电子·激光;1999年04期
相关博士学位论文 前3条
1 何芳;脂多糖致脑微血管内皮细胞通透性升高的机制研究[D];中南大学;2012年
2 戴丽娟;脑组织参数近红外实时在位微创测量技术及其应用研究[D];南京航空航天大学;2008年
3 腾轶超;近红外空间分辨光谱技术及其在脑氧无损检测中的应用[D];清华大学;2006年
相关硕士学位论文 前1条
1 王雪娜;基于近红外光的创伤性脑水肿无创监测技术研究[D];南京航空航天大学;2012年
，本文编号：2206127
本文链接：https://www.wllwen.com/yixuelunwen/shenjingyixue/2206127.html
最近更新
教材专著
