MR脑灌注成像在青年大脑中动脉狭窄预后评估中的价值
发布时间：2018-10-14 09:01
【摘要】：目的：分析MR脑灌注成像在青年大脑中动脉狭窄预后评估中的价值 方法：回顾性分析于2011年1月至2012年1月于济宁医学院附属医院神经内科住院,症状为反复短暂性脑缺血发作,并经DSA证实的单侧大脑中动脉狭窄或闭塞患者的临床资料,患者年龄45岁,共计60名。随机选取年龄、性别等匹配的健康查体者60名作为对照。根据DSA结果进行大脑中动脉狭窄程度分组,分为轻度狭窄(0—29%)组,中度狭窄(30—69%)组,重度狭窄或闭塞(70%以上)组,在TIA发作间歇期行磁共振脑灌注成像(PWI)检查,记录PWI参数。随访1—2年,病例组根据梗死分组,分为梗死组或非梗死组,根据PWI参数探讨不同狭窄程度梗死组与非梗死组差异。 结果：1.单侧MCA轻度狭窄组12例,梗死组与非梗死组狭窄区PWI参数无明显差异。2.单侧MCA中度狭窄组28例,狭窄区PWI提示梗死组rMTT、rTTP较非梗死组延迟。3.单侧MCA重度狭窄或闭塞组20例,狭窄区PWI提示梗死组rCBV较非梗死组下降,rMTT、rTTP明显延迟。 结论：1.PWI对MCA狭窄中度以上患者进行预后评估较轻度狭窄意义大。 2.磁共振PWI快速,操作简单,患者易于耐受,能反映全脑组织微血管结构的血流灌注情况,提供血流动力学方面的信息,是评价大脑中动脉狭窄预后的敏感指标。
[Abstract]:Objective: to evaluate the value of MR perfusion imaging in evaluating the prognosis of middle cerebral artery stenosis in young adults. Methods: retrospective analysis was conducted in the Department of Neurology, affiliated Hospital of Jining Medical College, from January 2011 to January 2012. The clinical data of patients with recurrent transient ischemic attack and unilateral middle cerebral artery stenosis or occlusion confirmed by DSA were 60 patients aged 45 years. Sixty matched age, sex and other health examiners were randomly selected as controls. According to the results of DSA, middle cerebral artery stenosis was divided into three groups: mild stenosis (0-29%), moderate stenosis (30-69%), severe stenosis or occlusion (more than 70%). Mr perfusion imaging (PWI) was performed during the interictal period of TIA. Record the PWI parameter. The patients were divided into infarction group and non-infarction group according to infarction group. The difference between infarction group and non-infarction group was discussed according to PWI parameters. The result is 1: 1. There was no significant difference in PWI parameters between infarct group and non infarction group in 12 patients with mild stenosis of unilateral MCA. There were 28 cases with moderate stenosis of unilateral MCA. The rMTT,rTTP in the infarct group was delayed by 3. 3% than that in the non-infarct group by PWI. There were 20 patients with severe stenosis or occlusion of unilateral MCA. PWI in the narrow area indicated that the rCBV in the infarction group was lower than that in the non-infarction group, and rMTT,rTTP was significantly delayed. Conclusion: the prognostic value of 1.PWI in patients with moderate or more MCA stenosis is higher than that in mild stenosis. 2. 2. Magnetic resonance imaging (PWI) is a sensitive index for evaluating the prognosis of middle cerebral artery stenosis. It can reflect the blood perfusion of the microvascular structure of the whole brain and provide hemodynamic information.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3
[Abstract]:Objective: to evaluate the value of MR perfusion imaging in evaluating the prognosis of middle cerebral artery stenosis in young adults. Methods: retrospective analysis was conducted in the Department of Neurology, affiliated Hospital of Jining Medical College, from January 2011 to January 2012. The clinical data of patients with recurrent transient ischemic attack and unilateral middle cerebral artery stenosis or occlusion confirmed by DSA were 60 patients aged 45 years. Sixty matched age, sex and other health examiners were randomly selected as controls. According to the results of DSA, middle cerebral artery stenosis was divided into three groups: mild stenosis (0-29%), moderate stenosis (30-69%), severe stenosis or occlusion (more than 70%). Mr perfusion imaging (PWI) was performed during the interictal period of TIA. Record the PWI parameter. The patients were divided into infarction group and non-infarction group according to infarction group. The difference between infarction group and non-infarction group was discussed according to PWI parameters. The result is 1: 1. There was no significant difference in PWI parameters between infarct group and non infarction group in 12 patients with mild stenosis of unilateral MCA. There were 28 cases with moderate stenosis of unilateral MCA. The rMTT,rTTP in the infarct group was delayed by 3. 3% than that in the non-infarct group by PWI. There were 20 patients with severe stenosis or occlusion of unilateral MCA. PWI in the narrow area indicated that the rCBV in the infarction group was lower than that in the non-infarction group, and rMTT,rTTP was significantly delayed. Conclusion: the prognostic value of 1.PWI in patients with moderate or more MCA stenosis is higher than that in mild stenosis. 2. 2. Magnetic resonance imaging (PWI) is a sensitive index for evaluating the prognosis of middle cerebral artery stenosis. It can reflect the blood perfusion of the microvascular structure of the whole brain and provide hemodynamic information.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3
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