视神经脊髓炎谱系疾病患者脑脊液蛋白水平与致残状况的相关性研究

发布时间：2018-10-21 11:43

【摘要】：目的探讨视神经脊髓炎谱系疾病(Neuromyelitis optica disorders,NMOSDs)患者脑脊液蛋白与临床致残状况的关系及其临床意义。方法回顾性分析2010年1月~2016年2月我院神经内科确诊的108例NMOSD患者临床与生化资料,根据临床扩展致残量表评分(Expanded disability status scale,EDSS)将患者分为独立行走受限与不受限组,并比较两组患者间的临床、生化特征;根据脑脊液蛋白值将患者分为脑脊液蛋白正常组与异常组,并比较两组间EDSS评分的变化;分析脑脊液蛋白与临床致残状况的相关性。结果独立行走受限组与不受限组之间患者年龄、二便障碍、外周血白细胞(WBC)、中性粒细胞比(N%)、脑脊液蛋白、脑脊液Ig G较有统计学差异(P0.05);性别、病程、视力损害、AQP4抗体、24 h鞘内合成率、寡克隆带比较无统计学差异(P0.05),两组不同脑脊液蛋白水平与患者EDSS值比较有统计学差异(T=3.13,P=0.002);脑脊液蛋白水平与独立行走受限呈正相关(r=0.286,P0.01)。结论 NMOSD患者脑脊液蛋白值越高,患者致残发生的可能性越大,脑脊液蛋白有助于视神经脊髓炎谱系疾病患者致残状况的病情评估。
[Abstract]:Objective to investigate the relationship between cerebrospinal fluid protein (CSF) and clinical disability in patients with optic neuromyelitis (Neuromyelitis optica disorders,NMOSDs) and its clinical significance. Methods the clinical and biochemical data of 108 patients with NMOSD diagnosed by neurology from January 2010 to February 2016 were retrospectively analyzed. According to the clinical extended disability scale (Expanded disability status scale,EDSS), the patients were divided into two groups: independent walking restricted group and non-restricted group. The clinical and biochemical characteristics of the two groups were compared. According to the cerebrospinal fluid protein value, the patients were divided into normal CSF protein group and abnormal cerebrospinal fluid protein group, and the changes of EDSS score between the two groups were compared, and the correlation between CSF protein and clinical disability was analyzed. Results there were significant differences in age, defecation disorder, (WBC), neutrophil ratio (N%), cerebrospinal fluid protein (CSF) and cerebrospinal fluid (Ig G) between the independent walking restricted group and the non-restricted group (P0.05). There was no significant difference in visual impairment, AQP4 antibody, 24 h intrathecal synthesis rate and oligoclonal band (P0.05). There was significant difference between the two groups in cerebrospinal fluid protein level and EDSS value (T = 3.13), and cerebrospinal fluid protein level was positively correlated with independent walk restriction (r = 0.286, P 0.01). Conclusion the higher the cerebrospinal fluid protein value in NMOSD patients, the greater the possibility of disability. CSF protein is helpful to evaluate the disability status of patients with optic neuromyelitis spectrum disease.
【作者单位】：第二军医大学附属长海医院神经内科;
【基金】：国家自然科学基金面上项目(No.81471219)
【分类号】：R744.52

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