血清尿酸与大动脉粥样硬化型缺血性脑卒中的相关性研究
发布时间：2018-11-22 12:55
【摘要】：目的： 探讨大动脉粥样硬化型缺血性脑卒中(Large artery atherosclerosis ischemicstroke, LAA)急性期血清尿酸（Serum uric acid, SUA）与其病情严重程度、其他相关危险因素及短期预后的相关性，为临床科学治疗大动脉粥样硬化型缺血性脑卒中，改善其预后提供依据。 方法： 选取2012年12月到2013年12月在发病1天之内入住郴州市第一人民医院神经内科治疗并确诊的大动脉粥样硬化型缺血性脑卒中的患者282例作为病例组；对照组为同期门诊性别、年龄匹配的282例健康体检者。病例组及对照组均记录一般临床资料（性别、年龄、高血压、、糖尿病、吸烟、饮酒等）、测定相关生化指标等，入院后14天或出院时行MRS评分。单因素及Logistic回归分析大动脉粥样硬化型缺血性脑卒中急性期血清尿酸与其病情严重程度、其他相关危险因素及短期预后的相关性。 结果： 1、病例组高血压、糖尿病患病率及吸烟、饮酒史明显高于对照组（P0.05），病例组SUA、SBP、DBP、TG、LDL、HsCRP、 Fib、BMI较对照组高（P0.05）。 2、单因素方差分析显示轻度、中度、重度缺血性脑卒中三型之间血清尿酸水平差异有统计学意义，P0.01。再对不同病情程度的缺血性脑卒中的血清尿酸行两两之间的LSD-T检验，差异仍有统计学意义。 3、相关分析得出在大动脉粥样性硬化型缺血性脑卒中急性期血清尿酸与SBP、TG、FBG、LDL、HsCRP成正相关（P0.05）。 4、单因素分析大动脉粥样性硬化型缺血性脑卒中预后良好组与预后不良组，高尿酸血症、年龄、高血压、糖尿病、FBG、LDL、HsCRP、BMI、NIHSS(病情严重程度)有统计学意义（P0.05）。logistic逐步回归分析表明年龄、糖尿病、LDL、HsCRP、病情严重程度为预后不良的危险指标，而高尿酸血症不能作为预后不良的独立的预测因素。 结论： 1、大动脉粥样硬化型缺血性脑卒中急性期血清尿酸与病情严重程度相关，病情越重，，血清尿酸水平越高。 2、大动脉粥样硬化型缺血型脑卒中急性期血清尿酸与SBP、TG、FBG、LDL、HsCRP成正相关。 3、急性期血清尿酸不是大动脉粥样硬化型缺血性脑卒中短期预后的独立预测因素，可能是疾病发展过程中表现出来的血清学异常的指标。
[Abstract]:Objective: to investigate the correlation between serum uric acid (Serum uric acid, SUA) and severity, other risk factors and short-term prognosis of (Large artery atherosclerosis ischemicstroke, LAA) in patients with atherosclerotic stroke. To provide a basis for clinical treatment of atherosclerotic ischemic stroke and improve its prognosis. Methods: 282 patients with atherosclerotic ischemic stroke who were admitted to the Department of Neurology of the first people's Hospital of Chenzhou from December 2012 to December 2013 were selected as the case group. The control group consisted of 282 healthy persons who matched the sex and age of outpatient service in the same period. The general clinical data (sex, age, hypertension, diabetes, smoking, alcohol consumption, etc.) were recorded in both the case group and the control group. The MRS scores were measured on the 14th day after admission or at the time of discharge. Univariate and Logistic regression analysis were used to study the correlation between serum uric acid and severity, other risk factors and short-term prognosis in acute stage of atherosclerotic ischemic stroke. Results: 1. The prevalence of hypertension, diabetes, smoking and alcohol consumption in the case group was significantly higher than that in the control group (P0.05), and the SUA,SBP,DBP,TG,LDL,HsCRP, Fib,BMI in the case group was higher than that in the control group (P0.05). 2. Univariate ANOVA showed significant difference in serum uric acid levels among mild, moderate and severe ischemic stroke types (P0.01). The serum uric acid of ischemic stroke with different degree of disease was tested by LSD-T, and the difference was statistically significant. 3, correlation analysis showed that serum uric acid was positively correlated with SBP,TG,FBG,LDL,HsCRP in the acute phase of atherosclerotic ischemic stroke (P0.05). Univariate analysis of good prognosis and poor prognosis of atherosclerotic ischemic stroke, hyperuricemia, age, hypertension, diabetes, FBG,LDL,HsCRP,BMI, NIHSS (severity of disease) was statistically significant (P0.05). Logistic stepwise regression analysis showed that age, diabetes, LDL,HsCRP, severity were the risk indicators of poor prognosis. Hyperuricemia is not an independent predictor of poor prognosis. Conclusion: 1. The serum uric acid level is related to the severity of the disease in the acute phase of atherosclerotic ischemic stroke. The more serious the condition, the higher the serum uric acid level. 2. There was a positive correlation between serum uric acid and SBP,TG,FBG,LDL,HsCRP in acute stage of atherosclerotic cerebral apoplexy. 3. Serum uric acid in acute stage is not an independent predictor of short-term prognosis of atherosclerotic ischemic stroke, and may be an indicator of serological abnormalities in the course of disease development.
【学位授予单位】：南华大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3
本文编号：2349435
[Abstract]:Objective: to investigate the correlation between serum uric acid (Serum uric acid, SUA) and severity, other risk factors and short-term prognosis of (Large artery atherosclerosis ischemicstroke, LAA) in patients with atherosclerotic stroke. To provide a basis for clinical treatment of atherosclerotic ischemic stroke and improve its prognosis. Methods: 282 patients with atherosclerotic ischemic stroke who were admitted to the Department of Neurology of the first people's Hospital of Chenzhou from December 2012 to December 2013 were selected as the case group. The control group consisted of 282 healthy persons who matched the sex and age of outpatient service in the same period. The general clinical data (sex, age, hypertension, diabetes, smoking, alcohol consumption, etc.) were recorded in both the case group and the control group. The MRS scores were measured on the 14th day after admission or at the time of discharge. Univariate and Logistic regression analysis were used to study the correlation between serum uric acid and severity, other risk factors and short-term prognosis in acute stage of atherosclerotic ischemic stroke. Results: 1. The prevalence of hypertension, diabetes, smoking and alcohol consumption in the case group was significantly higher than that in the control group (P0.05), and the SUA,SBP,DBP,TG,LDL,HsCRP, Fib,BMI in the case group was higher than that in the control group (P0.05). 2. Univariate ANOVA showed significant difference in serum uric acid levels among mild, moderate and severe ischemic stroke types (P0.01). The serum uric acid of ischemic stroke with different degree of disease was tested by LSD-T, and the difference was statistically significant. 3, correlation analysis showed that serum uric acid was positively correlated with SBP,TG,FBG,LDL,HsCRP in the acute phase of atherosclerotic ischemic stroke (P0.05). Univariate analysis of good prognosis and poor prognosis of atherosclerotic ischemic stroke, hyperuricemia, age, hypertension, diabetes, FBG,LDL,HsCRP,BMI, NIHSS (severity of disease) was statistically significant (P0.05). Logistic stepwise regression analysis showed that age, diabetes, LDL,HsCRP, severity were the risk indicators of poor prognosis. Hyperuricemia is not an independent predictor of poor prognosis. Conclusion: 1. The serum uric acid level is related to the severity of the disease in the acute phase of atherosclerotic ischemic stroke. The more serious the condition, the higher the serum uric acid level. 2. There was a positive correlation between serum uric acid and SBP,TG,FBG,LDL,HsCRP in acute stage of atherosclerotic cerebral apoplexy. 3. Serum uric acid in acute stage is not an independent predictor of short-term prognosis of atherosclerotic ischemic stroke, and may be an indicator of serological abnormalities in the course of disease development.
【学位授予单位】：南华大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3
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