干细胞治疗缺血性脑卒中的抗炎效应

发布时间：2019-03-03 16:44

【摘要】：背景:基础实验已表明,干细胞具有免疫正调节能力和细胞替代功能。目的:总结干细胞移植治疗缺血性脑卒的抗炎效应,在此基础上进一步讨论其具体的机制。方法:以"stem cells,stroke,inflammation,immune"为关键词,应用计算机检索2012至2017年PubMed、Elsevier、Springer、Wiley、ovid、EBSCO等数据库中的文献,共搜索到文献110篇,最终纳入47篇文献。结果与结论:神经干细胞、间充质干细胞、内皮组细胞等干细胞移植治疗缺血性脑卒的抗炎效应,主要包括减少局灶性炎症反应,免疫调节,促进多种神经营养因子的分泌,减少继发性细胞死亡,保护神经元,促进细胞功能恢复进而促进神经功能的恢复。干细胞的局部免疫调节和抑炎作用主要体现在其分泌因子作用于巨噬细胞,使其发生M1到M2型转化,干预免疫分泌的细胞因子图谱,并对胶质细胞进行抑制和极化等。干细胞移植治疗脑卒中的抗炎效应和免疫调节功能亟需深入的研究。
[Abstract]:Background: basic experiments have shown that stem cells have the ability of positive immune regulation and cell replacement. Aim: to summarize the anti-inflammatory effect of stem cell transplantation on ischemic stroke and discuss its specific mechanism. Methods: using "stem cells,stroke,inflammation,immune" as a key word, a computer search was carried out in PubMed,Elsevier,Springer,Wiley,ovid,EBSCO and other databases from 2012 to 2017. A total of 110 articles were searched, and 47 articles were finally included. Results & conclusion: the anti-inflammatory effects of neural stem cells, mesenchymal stem cells and endothelial cells in the treatment of ischemic stroke mainly include reducing focal inflammatory response, immunomodulation, and promoting the secretion of multiple neurotrophic factors. Reduce secondary cell death, protect neurons, promote cell function recovery and promote neural function recovery. The local immunomodulation and anti-inflammatory effects of stem cells are mainly reflected in the action of secreting factors on macrophages, the transformation from M1 to M2, the intervention of cytokine profiles of immune secretion, and the inhibition and polarization of glial cells. The anti-inflammatory effect and immunomodulatory function of stem cell transplantation in cerebral apoplexy need further study.
【作者单位】：江苏大学附属上海市第八人民医院;同济大学医学院;解放军第102医院;贵州医科大学;
【基金】：国家自然科学基金(31601102)~~
【分类号】：R743.3

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