缺血性脑卒中复发与阿司匹林抵抗的相关性研究

发布时间：2019-04-11 19:34

【摘要】：目的观察缺血性脑梗死初发以及复发患者阿司匹林(ASP)疗效,探讨缺血性脑梗死复发与阿司匹林抵抗(AR)的关系,并对复发患者的危险因素进行相关性分析。方法采用回顾性研究方法,将急性缺血性脑梗死患者分为初发组和复发组,复发组入院后即行血栓弹力图(TEG)检测,初发组规律服用ASP后1 m进行TEG检测,比较初发组及复发组AR发生率。并对患者生化指标、TOAST分型及危险因素等进行Logistic回归分析,探讨缺血性脑梗死复发的临床相关因素。结果初发组AR发生率为28.57%;复发组AR发生率为56.76%。复发组AR明显高于初发组(P0.01)。糖尿病、冠心病在复发组出现率高(P0.05);年龄、性别、吸烟、饮酒、高血压、高脂血症、动脉粥样硬化型、BMI、TG、CHOL、LDL、HDL、HCY及hs-CRP的水平两组差异无显著性(P0.05)。对P0.1危险因素的Logistic回归分析示AR、糖尿病与缺血性脑梗死复发明显相关。结论 AR能显著增加缺血性脑梗死复发风险;糖尿病增加缺血性脑梗死复发风险。
[Abstract]:Aim to observe the efficacy of aspirin (ASP) in patients with primary and recurrent ischemic cerebral infarction, to explore the relationship between the recurrence of ischemic cerebral infarction and aspirin resistance to (AR), and to analyze the risk factors of recurrent patients. Methods the patients with acute ischemic cerebral infarction were divided into two groups: the initial group and the recurrent group. The (TEG) of thrombus elastogram was detected immediately after admission in the recurrent group, and TEG was detected in the first group at 1 m after taking ASP regularly, and the patients in the first group were divided into two groups: the first group and the recurrent group. The incidence of AR was compared between the initial group and the recurrent group. The biochemical indexes, TOAST classification and risk factors of the patients were analyzed by Logistic regression analysis to explore the clinical factors related to the recurrence of ischemic cerebral infarction. Results the incidence of AR was 28.57% in the first onset group and 56.76% in the recurrent group. The AR in recurrent group was significantly higher than that in initial group (P0.01). The occurrence rate of diabetes mellitus and coronary heart disease in recurrent group was higher (P0.05); There was no significant difference in age, sex, smoking, drinking, hypertension, hyperlipidemia, atherosclerosis, BMI,TG,CHOL,LDL,HDL,HCY and hs-CRP levels between the two groups (P0.05). Logistic regression analysis of P 0.1 risk factors showed that AR, diabetes mellitus was significantly correlated with recurrence of ischemic cerebral infarction. Conclusion AR can significantly increase the risk of recurrence of ischemic cerebral infarction and diabetes mellitus can increase the risk of recurrence of ischemic cerebral infarction.
【作者单位】：河北医科大学第三医院神经外科;河北医科大学第二医院神经内科神经病学河北省重点实验室;
【基金】：河北省科技厅项目(No.15967727D)
【分类号】：R743.3

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