不同治疗方案对老年胶质母细胞瘤患者生存期的影响
发布时间:2019-07-29 12:17
【摘要】:目的研究不同治疗方案对老年胶质母细胞瘤患者生存期的影响。方法采用单因素生存分析法,生存曲线的比较采用log-rank检验,多因素生存分析采用Cox回归模型,分析治疗方案、年龄、是否服用替莫唑胺、KPS评分、肿瘤部位、大小等因素对生存时间的影响。结果通过单因素生存分析,老年胶质母细胞瘤患者的生存期与其治疗方案(放疗、手术局部切除、手术全部切除)、年龄(≤75岁、75岁)、是否服用替莫唑胺、KPS评分(70分、70~90分、90分)等因素有关(P0.05);而生存期与肿瘤部位(额、颞、顶、枕叶)、大小(≤4 cm、4 cm)无关(P0.05)。多因素分析:治疗方案为手术全部切除、服用替莫唑胺、KPS评分越高(70分、70~90分、90分)等因素为老年胶质母细胞瘤患者的生存期保护因素(P0.05);而年龄越大则表现为危险因素(P0.05)。生存期与肿瘤部位(额、颞、顶、枕叶)、大小(≤4 cm、4 cm)等因素的分析提示差异无统计学意义(P0.05)。结论治疗方案为手术全部切除、服用替莫唑胺、KPS评分越高(70分、70~90分、90分)等因素为老年胶质母细胞瘤患者的生存期的保护因素;年龄越大则表现为危险因素。肿瘤大小及肿瘤部位对中位生存时间无明显影响。
[Abstract]:Objective to study the effect of different treatments on the survival time of elderly patients with glioblastomas. Methods single factor survival analysis was used, log-rank test was used to compare survival curve, and Cox regression model was used for multivariate survival analysis. The effects of treatment plan, age, whether or not to take temozolamine, KPS score, tumor location and size on survival time were analyzed. Results by univariate survival analysis, the survival time of elderly patients with glioblastomas was related to the treatment regimen (radiotherapy, local resection, total resection), age (鈮,
本文编号:2520499
[Abstract]:Objective to study the effect of different treatments on the survival time of elderly patients with glioblastomas. Methods single factor survival analysis was used, log-rank test was used to compare survival curve, and Cox regression model was used for multivariate survival analysis. The effects of treatment plan, age, whether or not to take temozolamine, KPS score, tumor location and size on survival time were analyzed. Results by univariate survival analysis, the survival time of elderly patients with glioblastomas was related to the treatment regimen (radiotherapy, local resection, total resection), age (鈮,
本文编号:2520499
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