Nrf2在神经退行性疾病中的作用
发布时间:2021-03-19 14:19
核因子E2相关因子2(nuclear facter erythroid 2-related facter 2, Nrf2)是细胞中抗氧化转录因子,在机体内起到重要的抗氧化作用。研究表明,Nrf2可以通过抑制氧化应激,降低神经炎症及改善线粒体功能等作用,缓解神经退行性疾病。本文就Nrf2的结构及其在神经退行性疾病中的作用进行综述,以期为神经退行性疾病的防治策略提供新思路。
【文章来源】:生命的化学. 2020,40(11)
【文章页数】:8 页
【部分图文】:
Nrf2的结构示意图[3]
【参考文献】:
期刊论文
[1]Keap1-Nrf2-ARE信号通路及其激活剂的研究进展[J]. 姚娟,吴平安,李芸,李越峰,刘东玲,刘雪枫. 中国药理学通报. 2019(10)
[2]Effect of p62 on tau hyperphosphorylation in a rat model of Alzheimer’s disease[J]. Xianhong Zheng1,Weiwei Wang2,Ruizhi Liu1,Honglan Huang3,Rihui Zhang4,Liankun Sun2 1Department of Cytobiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 2Department of Pathophysiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 3Department of Pathogen Biology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 4Department of Physiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China. Neural Regeneration Research. 2012(17)
本文编号:3089719
【文章来源】:生命的化学. 2020,40(11)
【文章页数】:8 页
【部分图文】:
Nrf2的结构示意图[3]
【参考文献】:
期刊论文
[1]Keap1-Nrf2-ARE信号通路及其激活剂的研究进展[J]. 姚娟,吴平安,李芸,李越峰,刘东玲,刘雪枫. 中国药理学通报. 2019(10)
[2]Effect of p62 on tau hyperphosphorylation in a rat model of Alzheimer’s disease[J]. Xianhong Zheng1,Weiwei Wang2,Ruizhi Liu1,Honglan Huang3,Rihui Zhang4,Liankun Sun2 1Department of Cytobiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 2Department of Pathophysiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 3Department of Pathogen Biology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 4Department of Physiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China. Neural Regeneration Research. 2012(17)
本文编号:3089719
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