线粒体Smac蛋白与Bcl-2蛋白家族的相关性及其促凋亡机制研究进展

发布时间：2018-05-29 19:50

本文选题：Smac + 信号通路　；参考：《中国资源综合利用》2015年11期

【摘要】：细胞凋亡又称程序性细胞死亡,在机体发育分化和维持体内平衡中起着十分重要的作用。机体内存在两类影响细胞凋亡的基因,即促凋亡基因,如Bax、Smac、Htr A2和抗凋亡基因,如Bcl-2、IAPs、p53。Smac是一种线粒体促凋亡蛋白,在凋亡信号刺激下,它与细胞色素C(cytochrome c,cytc)一同释放进入细胞质,经修饰形成成熟的Smac,与Caspase竞争结合IAPs,解除IAPs的抑制作用,激活Caspase,从而促发凋亡。Bcl-2家族蛋白是在细胞凋亡过程中起关键性作用的一类蛋白质,根据Bcl-2家族蛋白的功能,可将其分为两大类:促凋亡Bcl-2蛋白和抗凋亡Bcl-2蛋白。近年来,关于Smac信号通路和Bcl-2家族蛋白相关性的研究越来越多。因此,深入研究其分子机制,可为肿瘤的基因治疗、药物靶点的筛选及抗肿瘤药物的开发提供新的思路。
[Abstract]:Apoptosis, also known as programmed cell death, plays an important role in the development, differentiation and balance of the body. There are two kinds of genes that affect cell apoptosis in the body, namely, apoptotic genes, such as Baxan-Smaca Htr A2 and anti-apoptotic genes, such as Bcl-2P53.Smac, a mitochondrial apoptosis-promoting protein, which is released into the cytoplasm with cytochrome C(cytochrome ct cc under the stimulation of apoptosis signal. Modified to form mature Smacs, compete with Caspase to bind IAPs, remove the inhibitory effect of IAPs, activate Caspase, thus promote apoptosis. Bcl-2 family proteins are a class of proteins that play a key role in the process of apoptosis. According to the function of Bcl-2 family proteins, It can be divided into two categories: apoptotic Bcl-2 protein and anti-apoptotic Bcl-2 protein. In recent years, more and more researches have been done on the correlation between Smac signaling pathway and Bcl-2 family proteins. Therefore, further study of its molecular mechanism can provide new ideas for gene therapy, drug target screening and development of antitumor drugs.
【作者单位】：陇南师范高等专科学校生命科学与技术系;
【分类号】：R329.2

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