胎儿卵圆孔早闭4例尸体解剖分析

发布时间：2018-06-05 16:20

本文选题：卵圆孔早闭 + 胎儿　；参考：《诊断病理学杂志》2015年05期

【摘要】：目的探讨胎儿卵圆孔早闭(PCEO)的尸体解剖学特点。方法收集4例卵圆孔早闭胎儿的临床资料,测量心脏的大体情况,观察镜下特点。结果 4例胎儿中,1例因胎儿窘迫就诊,3例为孕期超声心动图检查发现胎儿心脏畸形引产。病理解剖见心房扩张,以右心房明显,卵圆孔关闭呈膜状,3例可见卵圆孔痕迹,大小与正常卵圆孔一致;1例卵圆孔狭小,卵圆瓣贴附于卵圆孔上呈闭合状态;3例伴主动脉瓣闭锁及主动脉弓狭窄,2例伴二尖瓣闭锁,单心室及肺发育异常。镜下心肌呈缺血性改变,肺泡腔内出现渗出液及红细胞。结论卵圆孔早闭表现为胎儿期卵圆孔呈膜状闭合状态,可伴心房扩张或左心发育不良。
[Abstract]:Objective to study the anatomical characteristics of the early obturation of foetal foramen ovale (PCEO). Methods the clinical data of 4 fetuses with premature obturation of foramen ovale were collected. Results one case of fetal distress in 4 cases was diagnosed as fetal distress. 3 cases were found to be induced by fetal cardiac malformation by echocardiography during pregnancy. Pathological anatomy showed atrial dilatation, especially in the right atrium. The closing of the foramen ovale was membranous in 3 cases. The size of the foramen ovale was the same as that of the normal foramen ovale in 1 case, the size of the foramen ovale was narrow. The oval valve attached to the foramen ovale was closed in 3 cases with aortic valve atresia and aortic arch stenosis in 2 cases with mitral valve atresia and abnormal development of single ventricle and lung. Myocardial ischemic changes were observed under microscope, exudates and erythrocytes appeared in alveolar lumen. Conclusion the early closure of foramen ovale is characterized by membrane closure of foramen ovale in fetal stage, which may be accompanied by atrial dilation or dysplasia of left heart.
【作者单位】：首都医科大学附属北京安贞医院;北京市心肺血管疾病研究所病理科;北京市心肺血管疾病研究所超声诊断科;
【基金】：北京市优秀人才资助项目(2012A003C34000001) 首都医科大学基础临床科研合作基金课题(14JL56)
【分类号】：R322.1

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