上海市虹口区青少年人群百日咳全抗体水平监测

发布时间：2018-07-02 10:01

  本文选题：百日咳 + 抗体水平　； 参考：《中国生物制品学杂志》2015年12期

【摘要】：目的分析上海市虹口区青少年人群中百日咳全抗体水平,为人群百日咳免疫策略提供依据。方法 2010年在上海市虹口区内随机选择6~10岁、11~14岁及15~19岁的健康青少年225人,对青少年百日咳疫苗免疫史和持续≥14 d咳嗽史进行调查。采集静脉血样,分离血清,用ELISA法检测百日咳全抗体Ig G。结果实际纳入研究的对象共214人,百日咳疫苗全程接种率为93.93%,持续2周以上咳嗽患病率为15.42%;青少年人群百日咳全抗体GMT水平为21.88 U/ml,全抗体阳性(Ig G≥50 U/ml)率为26.64%,高抗体水平(Ig G≥100 U/ml)阳性率为15.42%;各年龄组百日咳全抗体GMT(F=19.90)、抗体阳性率(χ2=18.19)和高抗体水平阳性率(χ2=9.73)差异均有统计学意义(P0.01),随年龄增长均呈显著上升趋势(P0.01);1年内有持续2周以上咳嗽史人群百日咳全抗体GMT(t=2.505)、抗体阳性率(χ2=7.071)和高抗体水平阳性率(χ2=6.626)均明显高于无2周以上咳嗽史人群(P均0.05)。结论虹口区青少年人群中存在百日咳感染病例被漏诊或未发现;现行百日咳疫苗免疫程序对青少年不具有持久的保护作用。为虹口区青少年人群的百日咳疫苗免疫策略提供科学依据,有必要进一步开展医院/社区百日咳病例的前瞻性主动监测。
[Abstract]:Objective to analyze the total antibody level of pertussis in the adolescent population of Hongkou District, Shanghai, and to provide evidence for the population's pertussis immunization strategy. Methods 225 healthy adolescents aged 1114 and 1519 were randomly selected from Hongkou District of Shanghai in 2010 to investigate the history of immunization against pertussis vaccine and the history of cough lasting more than 14 days. Venous blood samples were collected and serum samples were isolated. The whole antibody Ig G of pertussis was detected by Elisa. Results A total of 214 subjects were actually included in the study. The total vaccination rate of pertussis vaccine was 93.93%, the prevalence of cough was 15.42%, the GMT level of pertussis total antibody was 21.88 U / ml, the total antibody positive rate (IgG 鈮，

本文编号：2089760