胃电活动模型分析与胃电慢波和蠕动波三维模拟

发布时间：2018-07-03 16:37

本文选题：胃电图 + 胃电活动　；参考：《扬州大学》2010年硕士论文

【摘要】： 胃的电机械活动是胃完成其正常生理功能的基础。多年来对胃的电机械活动的研究、建模和仿真已经有很多结果,但是,我们还没有看到胃电机械活动传播的模型及其三维动态模拟的相关报道。本论文的主要工作是分析胃电活动模型,建立胃电活动传导和蠕动收缩传播的三维模型,进而对其进行三维动态模拟。在阐述胃电机械活动的产生、特点及功能的基础上,本文首先用Matlab对离子机制的电活动模型进行分析和模拟,总结出不同类型细胞电活动的规律和特性,然后研究和模拟了电活动传导模型,最后建立了胃电机械活动关系和传播模型,并成功实现了用Matlab对胃的电机械活动的三维动态模拟。本文着重论述了逼近真实胃形态的三维胃模型和胃电机械活动耦合传播模型的建立及其Matlab模拟。本文用Matlab对传统离子机制的电活动模型H-H模型和FHN模型进行数学分析,并用图象来展示其电活动规律,通过比较和分析,总结出ICC细胞和平滑肌细胞之间不同的电活动规律和特性。分析模拟的结果不仅增进了我们对ICC细胞和平滑肌细胞功能作用的理解和认识,而且证明了这些胃电模型的合理性。本文对较成功的胃电活动传导的锥形体模型和柱导体模型进行研究,分析了电活动传导的规律。本文用这些模型建立的方法和原则建立了新的浆膜慢波传导模型,并用Matlab进行仿真。仿真结果反应了胃电活动传播规律,证实了传导模型的可靠性。本文首次实现了用Matlab建立和模拟了接近真实胃形态的三维胃模型。为了实现三维胃模型尽可能接近真实胃形态,我们用多个变形锥形体(或者柱形体)组合逼近静态胃形态,从而建立了静态胃的三维模型。我们详细阐述了三维胃模型建立的方法、原则,给出了用Matlab对其实现仿真的程序和仿真结果。本文首次对胃的电机械活动建立量化模型,并首次成功地实现了用Matlab对胃电机械活动的三维动态模拟。在所建立的三维胃模型基础上,根据实际胃生理,我们建立了胃电活动和蠕动收缩之间的量化关系模型,再由电机械耦合传导规律,进一步建立了胃电机械活动传导模型。最后用Matlab分别对静息胃的电活动传播和蠕动收缩胃的电机械活动的传播进行三维动态模拟,给出了相应的模拟结果。通过胃电机械活动的三维建模和三维动态模拟,形象地展现了胃电活动传播和胃蠕动收缩过程,为胃的电机械活动提供了三维动态模拟方法和新的认知途径。总之,我们的研究工作不仅增进了对胃电生理和胃动力的理解,而且通过对胃电机械活动三维建模和动态模拟,形象展现了胃电活动传播、胃蠕动收缩波的传播过程,形象地揭示了胃电活动与胃动力之间的关系。特别是为胃电活动与胃动力的研究和模拟提供新的研究和认识途径,使其在胃动力疾病研究和诊断中发挥更大的作用。
[Abstract]:The electromechanical activity of the stomach is the basis of its normal physiological function. There have been many results in the research, modeling and simulation of electromechanical activities of stomach for many years. However, we have not seen any reports on the model of electromechanical activity propagation and its three-dimensional dynamic simulation. The main work of this paper is to analyze the model of gastric electrical activity, to establish a three-dimensional model of gastric electrical conduction and peristaltic contraction, and then to simulate it dynamically. On the basis of expounding the generation, characteristics and functions of electromechanical activities of stomach, this paper first analyzes and simulates the electric activity model of ion mechanism with Matlab, and summarizes the laws and characteristics of different types of cell electrical activity. Then the conduction model of electromechanical activity is studied and simulated. Finally, the relationship and propagation model of electromechanical activity of stomach are established, and the three-dimensional dynamic simulation of electromechanical activity of stomach with Matlab is successfully realized. In this paper, the establishment and Matlab simulation of three-dimensional gastric model and coupled transmission model of electromechanical activity are discussed. In this paper, the mathematical analysis of H-H model and FHN model of traditional ion mechanism is carried out with Matlab, and the law of electrical activity is shown by image. Through comparison and analysis, the electric activity of H-H model and FHN model of traditional ion mechanism are compared and analyzed. Different patterns and characteristics of electrical activity between ICC cells and smooth muscle cells were summarized. The simulation results not only enhance our understanding of the function of ICC cells and smooth muscle cells, but also prove the rationality of these models. In this paper, the conical model and the column conductor model of gastric electrical conduction are studied, and the law of electrical conduction is analyzed. In this paper, a new serosal slow wave conduction model is established by using the methods and principles of these models, and the simulation is carried out with Matlab. The simulation results reflect the law of gastric electrical activity propagation and verify the reliability of the conduction model. In this paper, a three-dimensional gastric model is established and simulated by Matlab for the first time. In order to realize the three-dimensional gastric model as close as possible to the real gastric shape, we use several deformable cones (or columns) to approximate the static gastric shape, and establish a three-dimensional model of the static stomach. In this paper, the method and principle of establishing 3D gastric model are described in detail, and the program and result of simulation with Matlab are given. In this paper, a quantitative model of electromechanical activity of the stomach is established for the first time, and the three-dimensional dynamic simulation of the electromechanical activity of the stomach with Matlab is successfully realized for the first time. On the basis of the three-dimensional gastric model and the actual gastric physiology, we established a quantitative model of the relationship between gastric electrical activity and peristaltic contraction, and then further established the electromechanical conduction model of gastric electromechanical activity by electromechanical coupling conduction law. Finally, the electrokinetic propagation of resting stomach and the propagation of electromechanical activity of peristaltic contraction stomach were simulated by Matlab, respectively, and the corresponding simulation results were given. Through three-dimensional modeling and three-dimensional dynamic simulation of gastric electromechanical activity, the process of gastric electrical activity propagation and gastric peristalsis contraction is vividly demonstrated, which provides a three-dimensional dynamic simulation method and a new cognitive approach for gastric electromechanical activity. In a word, our research not only improves the understanding of gastric electrophysiology and gastric motility, but also shows the propagation process of gastric electrical activity and gastric peristaltic contraction wave by three-dimensional modeling and dynamic simulation of gastric electromechanical activity. The relationship between gastric electrical activity and gastric motility was vividly revealed. Especially, it provides a new research and understanding way for the study and simulation of gastric electrical activity and gastric motility, and makes it play a more important role in the study and diagnosis of gastric motility diseases.
【学位授予单位】：扬州大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R35

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