神经刺激电极的表面修饰方法研究

发布时间：2017-12-31 21:34

本文关键词：神经刺激电极的表面修饰方法研究　出处：《湘潭大学》2016年硕士论文　论文类型：学位论文

更多相关文章： 视觉假体 MEMS 微电极 铂灰 氧化铱

【摘要】：随着植入式生物医疗电子技术的发展,通过一定尺寸的微电极对人体的特定部位进行电刺激,能够达到传统药物或手术无法治愈的神经损伤性疾病的目的,例如老年性黄斑、面瘫以及视网膜色素变性等。但是,神经刺激电极在体内组织环境中经过长时间会慢慢老化,譬如电极阻抗值剧增和电极表面封装物脱落导致微电极的有效性以及可靠性变差。通过对微电极进行表面修饰可以有效地提高电学有效性和可靠性,针对微电极的表面修饰工作已经成为了近年来的研究热点。而电镀作为众多微电极表面修饰方法中最常用的方法,更是受到国内外广泛关注。本文首先主要研究了512刺激位点电极的加工工艺方法。然后再针对直径为200μm的铂电极进行表面修饰,对比分析了单独电镀铂灰、氧化铱以及铂灰和氧化铱复合涂层电学稳定性和可靠性。论文的主要结论如下:(1)为满足新一代高分辨率人造视网膜的工艺需求,针对柔性视网膜刺激微电极的设计及制作,研究了512刺激位点的植入式微电极阵列的加工工艺。(2)对直径200μm的铂电极进行表面修饰。通过Gamry600电化学工作站,对神经刺激微电极进行电化学表面阻抗测试和分析。通过线性电压扫描和体外循环伏安法测试确定了微电极适合电镀的最佳电势窗口和微电极在体外溶液体系中的稳定性。进行超声搅拌实验,通过观测实验中阻抗值的变化可以知道被修饰物与神经刺激微电极表面结合是否稳定。而无源加速老化实验,则可以模拟电极在体内一段时间后是否失效,有利于节约时间和经济成本。
[Abstract]:With the development of implantable biomedical electronic technology, electrical stimulation of specific parts of human body through a certain size of microelectrode can achieve the purpose of traditional medicine or surgery can not be cured of nerve injury diseases. For example, age-related macula, facial paralysis and retinitis pigmentosa, etc. However, nerve stimulation electrodes in the body over a long period of time in the tissue environment will slowly aging. For example, the increase of electrode impedance and the loss of encapsulation on the electrode surface lead to the deterioration of the validity and reliability of the microelectrode. The surface modification of the microelectrode can effectively improve the electrical efficiency and reliability. Surface modification of microelectrode has become a hot topic in recent years, and electroplating is the most commonly used method in many microelectrode surface modification methods. This paper mainly studied the processing technology of 512 stimulation site electrode. Then the surface modification of platinum electrode with diameter of 200 渭 m was carried out. The platinum ash electroplating was compared and analyzed. The electrical stability and reliability of iridium oxide and platinum ash and iridium oxide composite coatings. Design and fabrication of flexible retinal stimulation microelectrode. The fabrication process of 512-stimulation site implanted microelectrode array was studied. The platinum electrode with a diameter of 200 渭 m was modified by Gamry600 electrochemical workstation. The electrochemical surface impedance of nerve stimulated microelectrode was measured and analyzed. The optimum potential window and microelectrode suitable for electroplating were determined by linear voltage scanning and cardiopulmonary bypass voltammetry. Stability. Ultrasonic stirring experiment was carried out. By observing the change of impedance value in the experiment, we can know whether the surface of the modified electrode and the nerve stimulated microelectrode is stable, while the passive accelerated aging experiment can simulate whether the electrode will fail after a period of time in vivo. It is good for saving time and economic cost.
【学位授予单位】：湘潭大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：TG174.4;R318.08

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