细胞在三维结构中牵张力的产生及其应用

发布时间：2018-03-18 15:39

本文选题：细胞　切入点：力学　出处：《中国组织工程研究》2017年08期 　论文类型：期刊论文

【摘要】：背景:贴壁生长的细胞通过肌动-肌球蛋白之间的相互作用对细胞外基质或基底施加一定的牵张力,该过程与许多生理和病理过程密切相关。目的:综述了目前几种主要的细胞牵张力技术的基本原理及应用情况。方法:第一作者以"细胞牵张力、细胞力学"检索CNKI数据库、万方数据库,以"Cell traction force、Biomechanics"检索PubMed数据库、SpringerLink数据库。收入有关细胞牵张力测量方法的研究,排除重复研究。通过阅读,最终选取30篇文献进行综述,其中中文1篇,英文29篇。结果与结论:细胞牵张力的测量方法主要有3种:硅胶薄膜测量法、细胞牵张力显微镜技术、微组装悬臂梁。准确估算细胞牵张力,将进一步拓展对细胞-细胞以及细胞-微环境之间的力学作用等诸多基本问题的理解。
[Abstract]:Background: adherent cells exert a certain amount of tension on the extracellular matrix or substrate through the interaction between active-myosin. This process is closely related to many physiological and pathological processes. Objective: to review the basic principles and applications of several major cell stretch techniques. Methods: the first author searched the CNKI database by "Cell tension, Cell Mechanics". Wanfang database, Cell traction force Biomechanics, is used to retrieve PubMed database and SpringerLink database. Research on cell stretch measurement methods is introduced, and repeated research is excluded. Through reading, 30 articles are selected for review, including 1 in Chinese, 1 in Chinese, 1 in Chinese, 1 in Chinese, 1 in Chinese, 1 in Chinese, 1 in Chinese, 1 in Chinese, 1 in Chinese, 1 in Chinese. Results and conclusion: there are three main methods for measuring cell traction: silica gel film measurement, cell tension microscopy, microassembly cantilever beam. Understanding of the mechanical effects of cell-cell and cell-microenvironment will be further expanded.
【作者单位】：太原理工大学力学学院;
【基金】：国家自然科学基金资助项目(31271005,11402161,11402162)~~
【分类号】：R318

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