石墨烯量子点对小鼠小肠成像及微循环血流的影响

发布时间：2018-04-12 15:07

本文选题：石墨烯量子点 + 硫酸钡　；参考：《第二军医大学学报》2014年04期

【摘要】：目的研究石墨烯量子点(GQDs)对小鼠小肠的成像性能及对小鼠肠系膜微循环的影响。方法以纯水和碲化镉量子点(CdTe QDs)作为阴性及阳性对照,并与临床上常用的钡餐作对比,采用FX-in vivo小动物活体成像系统进行GQDs对C57BL/6N小鼠小肠的成像研究,用微循环显微镜观察其对肠系膜微动、静脉和毛细血管的影响。结果 GQDs灌胃1h后紫外光激发下小鼠小肠呈亮绿色充盈影像,肠壁边缘形态及黏膜细微结构清楚,肠系膜血管呈淡绿色影像;钡餐灌胃1h后X线照射下小肠呈高密度团块影像,肠壁黏膜细微结构不清楚,不能显示肠系膜血管。与灌胃前比,GQDs灌胃后小鼠肠系膜微动脉管径增大,而钡餐灌胃后微动脉管径减小;GQDs、CdTe QDs、钡餐灌胃对小鼠肠系膜微静脉管径均无明显影响;钡餐和CdTe QDs灌胃后小鼠肠系膜微动、静脉及毛细血管的血流速度加快,而GQDs灌胃对小鼠肠系膜微动、静脉及毛细血管的血流速度则无明显影响。结论 GQDs和钡餐均能对C57BL/6N小鼠小肠成像,GQDs对肠壁及黏膜的成像效果优于钡餐,对小鼠肠系膜微循环的影响较小。
[Abstract]:Aim to study the imaging properties of GQDs and the effect of GQDson mesenteric microcirculation in mice.Methods using pure water and cadmium telluride quantum dot CdTe QDsas negative and positive control, and comparing with barium meal, the small animal imaging system of FX-in vivo was used to study the small intestine imaging of C57BL/6N mice by GQDs.The microcirculation microscope was used to observe the effect of microcirculation on the mesenteric arterioles, veins and capillaries.The fine structure of the mucous membrane of the intestinal wall is not clear and does not show mesenteric vessels.The blood flow velocity of veins and capillaries was accelerated, but the blood flow velocity of mesenteric microvessels and veins was not significantly affected by GQDs.Conclusion both GQDs and barium meal have a better effect on the imaging of intestinal wall and mucosa in C57BL/6N mice, but have little effect on mesenteric microcirculation in mice.
【作者单位】：兰州大学口腔医学院修复教研室;中国科学院兰州化学与物理研究所固体润滑国家重点实验室;兰州大学口腔医学院外科学教研室;
【基金】：甘肃省科技支撑项目(1304FKCA074) 兰州大学口腔医学院科研扶持基金(533000-432363)~~
【分类号】：R318.08

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