数值模拟不同充气压力对支架术后颈动脉力学环境的影响

发布时间：2018-05-06 23:04

本文选题：动脉粥样硬化 + 斑块　；参考：《医用生物力学》2017年01期

【摘要】：目的研究支架介入在不同充气压力下对病变血管壁力学环境的影响。方法使用高分辨率磁共振成像(MRI)获得含有脂质斑块和钙化斑块的颈动脉模型,通过有限元软件构建体内血管-支架两者之间相互作用的力学模型,数值模拟分析不同充气压力(909、1 212和1 515 kPa)作用下血管壁及斑块的Von Mises应力分布。结果随着充气压力的增大,血管壁与支架接触内表面的Von Mises应力逐渐增大。在高充气压力作用下支架撑开后,脂质斑块区域会产生严重的应力集中现象;而在不同充气压力作用下,钙化斑块区域Von Mises应力分布差异很小。结论较大充气压力作用下支架撑开后将给血管壁和脂质斑块带来较大伤害,可能会引发支架后期失效。研究结果可为支架术充气压力的选择以及支架植入后斑块稳定性的预估提供临床参考。
[Abstract]:Objective to study the effect of stent intervention on the mechanical environment of diseased vascular wall under different inflatable pressure. Methods High resolution magnetic resonance imaging (MRI) was used to obtain carotid artery models with lipid plaque and calcified plaque. A mechanical model of the interaction between vascular and stent was constructed by finite element software. The Von Mises stress distribution of vascular walls and plaques under different inflatable pressures (909KPA, 1 212 and 1 515 KPA) was analyzed numerically. Results with the increase of inflatable pressure, the Von Mises stress on the inner surface of vascular wall and stent was gradually increased. When the scaffold was opened under high inflatable pressure, the stress concentration in lipid plaque region would be serious, but the stress distribution of Von Mises in calcified plaque region had little difference under different inflatable pressure. Conclusion when the stent is opened under the action of inflatable pressure, the vascular wall and lipid plaque will be damaged, which may lead to the later failure of the stent. The results can provide clinical reference for the selection of inflatable pressure and the prediction of plaque stability after stent implantation.
【作者单位】：北京航空航天大学生物与医学工程学院生物力学与力生物学教育部重点实验室;江苏理工学院机械工程学院;北京安贞医院放射科;
【基金】：国家自然科学基金项目(11332003,11421202,61190123,31200703,11472031)
【分类号】：R654.3;R318.01

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