含碳碳双键磷铵两性离子修饰聚氨酯材料的合成及性能研究

发布时间：2018-05-26 03:52

本文选题：磷铵两性离子 + 聚氨酯　；参考：《南京师范大学》2012年硕士论文

【摘要】：以2-甲基丙烯酰氧基乙基磷酰胆碱MPC为代表的磷铵两性离子修饰材料表面,有较好的抗凝血性和血液相容性,本论文从简单的原料三氯化磷和乙二醇出发,经过环构化、氧化、缩合、开环四步合成和MPC有类似结构的含碳碳双键的磷铵两性离子,这类反应的特点是,原料便宜易得,合成步骤简单,实验条件要求相对较低。并且通过红外、核磁等测试手段对合成产物进行了检测,图谱证实合成产物与预期的结构一致。聚氨酯是生物医药领域里常用的合成高分子材料,它广泛应用于人造血管、导管以及各种诊断治疗器械。但当聚氨酯材料与活体组织接触时,会导致血栓形成以及炎症等一些不良反应。这就对聚氨酯材料的生物相容性,尤其是血液相容性有一定的要求。而提高聚氨酯材料的血液相容性常用的方法有共混、表面涂层等物理方法,表面共价键合、接枝等化学方法。本文采用合成的含碳碳双键的磷铵两性离子通过物理共混和化学接枝两种方法对聚氨酯材料进行改性。并通过傅里叶变换红外光谱(ATR-FTIR)、表面水接触角(WCA)、热重分析(TGA)和力学性能等物理手段来表征接枝膜的结构、稳定性和亲水性能。实验结果也证明,两种方法改性后的聚氨酯材料的亲水性都有所提高。在此基础上,也通过蛋白质吸附、体外血小板粘附和溶血实验对材料的血液相容性进行了评价。结果也表明改性后聚氨酯材料的溶血率符合相关的国际标准,蛋白质吸附和血小板粘附都较少。
[Abstract]:The surface of amphoteric ammonium phosphate modified by 2-methacryloxy ethyl phosphatidylcholine (MPC) has good anticoagulant and blood compatibility. In this paper, phosphorus trichloride and ethylene glycol were used as raw materials, which were cyclized and oxidized. Condensation, ring-opening four-step synthesis of amphoteric ammonium phosphate with a similar structure to that of MPC with carbon-carbon double bonds is characterized by cheap raw materials, simple synthesis steps and relatively low experimental conditions. The synthesized products were detected by IR and NMR, and the structure of the synthesized products was confirmed to be in accordance with the expected structure. Polyurethane is a commonly used synthetic polymer material in the field of biomedicine. It is widely used in artificial blood vessels, catheters and various diagnostic and therapeutic instruments. However, some adverse reactions such as thrombosis and inflammation may occur when the polyurethane material is in contact with living tissue. This has certain requirements for the biocompatibility of polyurethane materials, especially for blood compatibility. The common methods to improve the blood compatibility of polyurethane are blending, surface coating, surface covalent bonding, grafting and other chemical methods. In this paper, the amphoteric ammonium phosphate containing carbon and carbon bonds was synthesized and modified by physical blending and chemical grafting. The structure, stability and hydrophilicity of the grafted films were characterized by Fourier transform infrared spectroscopy (FTIR), surface water contact angle (WCAA), thermogravimetric analysis (TGA) and mechanical properties. The experimental results also show that the hydrophilicity of the modified polyurethane is improved. On this basis, the blood compatibility of the materials was evaluated by protein adsorption, platelet adhesion and hemolysis in vitro. The results also showed that the hemolysis rate of the modified polyurethane was in accordance with the relevant international standards, and the protein adsorption and platelet adhesion were few.
【学位授予单位】：南京师范大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08

【参考文献】